Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107776
Abstract: Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells (RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We show that preventing the formation of neuroinflammatory… read more here.
Keywords: reactive astrocytes; death; neurotoxic reactive; injury ... See more keywords
Reactive Astrocytes: Production, Function, and Therapeutic Potential.
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.06.006
Abstract: Astrocytes constitute approximately 30% of the cells in the mammalian central nervous system (CNS). They are integral to brain and spinal-cord physiology and perform many functions important for normal neuronal development, synapse formation, and proper… read more here.
Keywords: reactive astrocytes; astrocytes production; function therapeutic; physiology ... See more keywords
EMT-like process in glioblastomas and reactive astrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2018.11.016
Abstract: &NA; The concept of the epithelial‐to‐mesenchymal transition (EMT) in epithelial cells has accelerated our understanding about cancer spreading. Fortunately, much of this information has been able to be extrapolated to non‐epithelial cancers, such as glioblastoma… read more here.
Keywords: reactive astrocytes; glioblastomas reactive; process glioblastomas; like process ... See more keywords
Reactive astrocytes prevent maladaptive plasticity after ischemic stroke
Sign Up to like & getrecommendations! Published in 2022 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2021.102199
Abstract: Restoration of functional connectivity is a major contributor to functional recovery after stroke. We investigated the role of reactive astrocytes in functional connectivity and recovery after photothrombotic stroke in mice with attenuated reactive gliosis (GFAP-/-Vim-/-).… read more here.
Keywords: maladaptive plasticity; connectivity; plasticity; recovery ... See more keywords
Neurotoxic reactive astrocytes induce cell death via saturated lipids.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03960-y
Abstract: Astrocytes regulate the response of the central nervous system to disease and injury and have been hypothesized to actively kill neurons in neurodegenerative disease1-6. Here we report an approach to isolate one component of the… read more here.
Keywords: reactive astrocytes; saturated lipids; astrocytes induce; induce cell ... See more keywords
Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2180202
Abstract: LCN2/neutrophil gelatinase-associated lipocalin/24p3 (lipocalin 2) is a secretory protein that acts as a mammalian bacteriostatic molecule. Under neuroinflammatory stress conditions, LCN2 is produced and secreted by activated microglia and reactive astrocytes, resulting in neuronal apoptosis.… read more here.
Keywords: reactive astrocytes; reduced secretion; lcn2; stress neuronal ... See more keywords
Upregulation of Annexin A1 in Reactive Astrocytes and Its Subtle Induction in Microglia at the Boundaries of Human Brain Infarcts.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlz079
Abstract: Annexin A1 (ANXA1) has multiple functions, including anti-inflammatory effects, and is thought to be neuroprotective in various pathophysiologies of the central nervous system. The importance of ANXA1 in microglia and endothelial cells in ischemic environments… read more here.
Keywords: reactive astrocytes; upregulation annexin; human brain; brain infarcts ... See more keywords
Dark side of astrocytes: Toxic, reactive astrocytes induced by activated microglia
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Neuroimmunology"
DOI: 10.1111/cen3.12388
Abstract: Astrocytes respond to injury and disease in the central nervous system, known as reactive astrogliosis. Liddelow et al. reported the three cytokines released by microglia are crucial to triggering the toxic astrocyte phenotype. These toxic… read more here.
Keywords: reactive astrocytes; toxic reactive; astrocytes induced; dark side ... See more keywords
Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes In Vivo and In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3800004
Abstract: Background/Aims. Multiple sclerosis (MS) is an autoimmune disorder that affects the central nervous system (CNS) primarily hallmarked by neuroinflammation and demyelination. The activation of astrocytes exerts double-edged sword effects, which perform an integral function in… read more here.
Keywords: reactive astrocytes; shen sui; sui capsule; medicine ... See more keywords
Abstract 2746: Stat3 labels a subpopulation of reactive astrocytes required for brain metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-2746
Abstract: The diagnosis of brain metastasis involves high morbidity and mortality and remains as an unmet clinical need in spite of being the most common tumor in the brain. Brain metastasis affects between 10-30% of cancer… read more here.
Keywords: reactive astrocytes; stat3; metastasis; biology ... See more keywords
An update on reactive astrocytes in chronic pain
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1524-2
Abstract: Chronic pain is a critical clinical problem with an increasing prevalence. However, there are limited effective prevention measures and treatments for chronic pain. Astrocytes are the most abundant glial cells in the central nervous system… read more here.
Keywords: reactive astrocytes; astrocytes chronic; nerve injury; chronic pain ... See more keywords