Regulating Astrocytes via Short Fibers for Spinal Cord Repair
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406742
Abstract: Reactive astrogliosis is the main cause of secondary injury to the central nerves. Biomaterials can effectively suppress astrocyte activation, but the mechanism remains unclear. Herein, Differentially Expressed Genes (DEGs) are identified through whole transcriptome sequencing… read more here.
Keywords: spinal cord; regulating astrocytes; short fibers; reactive astrogliosis ... See more keywords
Erythropoietin protects the subventricular zone and inhibits reactive astrogliosis in kaolin-induced hydrocephalic rats
Sign Up to like & getrecommendations! Published in 2019 at "Child's Nervous System"
DOI: 10.1007/s00381-019-04063-w
Abstract: PurposeTo elucidate the potential role of erythropoietin (EPO) as a neuroprotective agent against reactive astrogliosis and reducing the thinning rate of subventricular zone (SVZ) in kaolin-induced hydrocephalic rats.MethodThirty-six ten-week-old Sprague-Dawley rats were used in this… read more here.
Keywords: hydrocephalic rats; subventricular zone; reactive astrogliosis; group ... See more keywords
A Key Mediator and Imaging Target in Alzheimer’s Disease: Unlocking the Role of Reactive Astrogliosis Through MAOB
Sign Up to like & getrecommendations! Published in 2024 at "Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s13139-023-00837-y
Abstract: Astrocytes primarily maintain physiological brain homeostasis. However, under various pathological conditions, they can undergo morphological, transcriptomic, and functional transformations, collectively referred to as reactive astrogliosis. Recent studies have accumulated lines of evidence that reactive astrogliosis… read more here.
Keywords: alzheimer disease; role; pathology; astrogliosis ... See more keywords
CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.01.006
Abstract: Status epilepticus (SE) results in the unique pattern of dynamin-related protein 1 (DRP1)-mediated mitochondrial dynamics, which is associated with astroglial apoptosis and reactive astrogliosis in the regional-specific pattern representing the differential astroglial properties. However, less… read more here.
Keywords: cdk5 inhibitors; reactive astrogliosis; astroglial apoptosis;
The differential roles of PEA15 phosphorylations in reactive astrogliosis and astroglial apoptosis following status epilepticus
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Research"
DOI: 10.1016/j.neures.2018.02.003
Abstract: Up to this day, the roles of PEA15 expression and its phosphorylation in seizure-related events have not been still unclear. In the present study, we found that PEA15 was distinctly phosphorylated in reactive astrocytes and… read more here.
Keywords: roles pea15; phosphorylation; astroglial apoptosis; reactive astrogliosis ... See more keywords
PARP1-TRPM2-PKC cascade distinctly regulates reactive astrogliosis and clasmatodendrosis through NF-κB and AKT pathways in the hippocampus of chronic epilepsy rats
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-22229-2
Abstract: The epileptic hippocampi of rodent models show reactive astrogliosis and autophagic astroglial death (clasmatodendrosis) in the CA1 region, which contributes to spontaneous seizures. Oxidative stress upregulates transient receptor potential melastatin 2 (TRPM2, a non-selective Ca2+… read more here.
Keywords: astrogliosis clasmatodendrosis; phosphorylation; reactive astrogliosis; clasmatodendrosis ... See more keywords
Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15565
Abstract: Astrocytes are highly efficient homeostatic glial cells playing a crucial role in the optimal brain functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis following central nervous system (CNS) injury/diseased state by a specific… read more here.
Keywords: brain; reactive astrogliosis; astrogliosis friend; astrogliosis ... See more keywords
Acupuncture at ST36 Exerts Neuroprotective Effects via Inhibition of Reactive Astrogliosis in Infantile Rats with Hydrocephalus
Sign Up to like & getrecommendations! Published in 2018 at "Acupuncture in Medicine"
DOI: 10.1136/acupmed-2017-011515
Abstract: Background Acupuncture has been associated with improved cerebral circulation, analgesia, neuromodulatory function and neurogenesis. In particular, acupuncture at ST36 has been widely used in several central nervous system (CNS) disorders, including neurodegenerative diseases. However, its… read more here.
Keywords: astrogliosis infantile; acupuncture st36; reactive astrogliosis; acupuncture ... See more keywords
Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/9494352
Abstract: Astrocytes are the most populous glial cells in the central nervous system (CNS). They are essential to CNS physiology and play important roles in the maintenance of homeostasis, development of synaptic plasticity, and neuroprotection. Nevertheless,… read more here.
Keywords: astrogliosis implications; reactive astrogliosis; astrogliosis; cord injury ... See more keywords
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure
Sign Up to like & getrecommendations! Published in 2022 at "Toxicologic Pathology"
DOI: 10.1177/01926233221124497
Abstract: As regulators of homeostasis, astrocytes undergo morphological changes after injury to limit the insult in central nervous system (CNS). Trimethyltin (TMT) is a known neurotoxicant that induces reactive astrogliosis in rat CNS. To evaluate the… read more here.
Keywords: rat; learning; reactive astrogliosis; based segmentation ... See more keywords
Crystallin Alpha-B Overexpression as a Possible Marker of Reactive Astrogliosis in Human Cerebral Contusions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.838551
Abstract: The pathophysiology of traumatic brain injury (TBI) has not yet been fully elucidated. Crystallin alpha-B (CRYAB) is a molecular chaperone that apparently tries to stabilize the rapid thickening of the intermediate filaments of glial fibrillary… read more here.
Keywords: cryab; overexpression; expression; reactive astrogliosis ... See more keywords