Phospholipase activity of acyloxyacyl hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202149485
Abstract: Psoriasis is a chronic inflammatory skin disease characterized by Th17 responses. Recent evidence has identified Langerhans cells to have a key role in disease pathogenesis, with constitutive high expression of CD1a and capacity to present… read more here.
Keywords: acyloxyacyl hydrolase; individuals psoriasis; cd1a; activity ... See more keywords
Expansion and Determination of Antigen-Reactive T Cells by Flow Cytometry.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8979-9_10
Abstract: The detection of antigen-reactive T cells has shown great utility for patient clinical monitoring. However, many of the methods commonly used to detect these cells face major limitations, like the predetermination of the given HLA… read more here.
Keywords: determination antigen; expansion determination; reactive cells; antigen reactive ... See more keywords
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.07.009
Abstract: Cancer immunotherapies have shown substantial clinical activity for a subset of patients with epithelial cancers. Still, technological platforms to study cancer T-cell interactions for individual patients and understand determinants of responsiveness are presently lacking. Here,… read more here.
Keywords: tumor; tumor organoids; reactive cells; peripheral blood ... See more keywords
Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21241-0
Abstract: T cell rejuvenation by PD-1/PD-L1 blockade, despite emerging as a highly promising therapy for advanced cancers, is only beneficial for a minority of treated patients. There is evidence that a lack of efficient T cell… read more here.
Keywords: tumor; anti antibody; reactive cells; cell ... See more keywords
Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45449-y
Abstract: Immunotherapies targeting PD-1/PD-L1 are now widely used in the clinic to treat a variety of malignancies. While most of the research on T cell exhaustion and PD-1 blockade has been focused on conventional αβ T… read more here.
Keywords: blockade; response; cell; reactive cells ... See more keywords
Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60321-3
Abstract: Ultrasensitive antigen recognition between T lymphocytes and cognate targets via immunological synapse (IS) formation enables live cell-based antigen-specific T cell detection. However, unpredictable antigen processing and major histocompatibility complex (MHC) turnover limit specificity. Here, intracellularly… read more here.
Keywords: antigen; cell; identification; tumour reactive ... See more keywords
Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c8bm01556b
Abstract: Interleukin-2 (IL-2) is a potent T-cell mitogen that can adjuvant anti-cancer adoptive T-cell transfer (ACT) immunotherapy by promoting T-cell engraftment. However, the clinical applications of IL-2 in combination with ACT are greatly hindered by the… read more here.
Keywords: tumor; redox responsive; reactive cells; cell ... See more keywords
Frequency determination of breast tumor-reactive CD4 and CD8 T cells in humans: unveiling the antitumor immune response
Sign Up to like & getrecommendations! Published in 2019 at "OncoImmunology"
DOI: 10.1080/2162402x.2019.1607674
Abstract: ABSTRACT As cancer immunotherapy gains importance, the determination of a patient’s ability to react to his/her tumor is unquestionably relevant. Though the presence of T cells that recognize specific tumor antigens is well established, the… read more here.
Keywords: frequency; tumor reactive; reactive cells; tumor ... See more keywords
Bone marrow expands the repertoire of functional T cells targeting tumor-associated antigens in patients with resectable non-small-cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2019.1671762
Abstract: ABSTRACT The efficacy of cancer immunotherapy may be improved by increasing the number of circulating tumor-reactive T cells. The bone marrow is a priming site and reservoir for such T cells. The characteristics of bone… read more here.
Keywords: reactive cells; bone marrow; tumor; tumor reactive ... See more keywords
The 35th annual meeting of the Japanese Society for Neuroimmunology (JSNI)
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Experimental Neuroimmunology"
DOI: 10.1111/cen3.12778
Abstract: Objectives : Multiple sclerosis (MS) is associated with the activation of CD4 + T helper (Th) cells by self-antigen from the central nervous system (CNS) to generate pathogenic self-reactive Th cells. Treatment of such autoimmune… read more here.
Keywords: neuroimmunology; self reactive; annual meeting; 35th annual ... See more keywords
Nuclear long diameter as a new criterion to distinguish high‐grade urothelial carcinoma cells from benign reactive cells
Sign Up to like & getrecommendations! Published in 2024 at "Cytopathology"
DOI: 10.1111/cyt.13397
Abstract: Recently, the nuclear area has attracted attention as a morphological parameter to differentiate high‐grade urothelial carcinoma (HGUC) cells from benign reactive cells. The nuclear long diameter (NLD) strongly correlates with the nuclear area and is… read more here.
Keywords: urothelial carcinoma; high grade; grade urothelial; cells benign ... See more keywords