Phospholipase activity of acyloxyacyl hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202149485
Abstract: Psoriasis is a chronic inflammatory skin disease characterized by Th17 responses. Recent evidence has identified Langerhans cells to have a key role in disease pathogenesis, with constitutive high expression of CD1a and capacity to present… read more here.
Keywords: acyloxyacyl hydrolase; individuals psoriasis; cd1a; activity ... See more keywords
Expansion and Determination of Antigen-Reactive T Cells by Flow Cytometry.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8979-9_10
Abstract: The detection of antigen-reactive T cells has shown great utility for patient clinical monitoring. However, many of the methods commonly used to detect these cells face major limitations, like the predetermination of the given HLA… read more here.
Keywords: determination antigen; expansion determination; reactive cells; antigen reactive ... See more keywords
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.07.009
Abstract: Cancer immunotherapies have shown substantial clinical activity for a subset of patients with epithelial cancers. Still, technological platforms to study cancer T-cell interactions for individual patients and understand determinants of responsiveness are presently lacking. Here,… read more here.
Keywords: tumor; tumor organoids; reactive cells; peripheral blood ... See more keywords
Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21241-0
Abstract: T cell rejuvenation by PD-1/PD-L1 blockade, despite emerging as a highly promising therapy for advanced cancers, is only beneficial for a minority of treated patients. There is evidence that a lack of efficient T cell… read more here.
Keywords: tumor; anti antibody; reactive cells; cell ... See more keywords
Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c8bm01556b
Abstract: Interleukin-2 (IL-2) is a potent T-cell mitogen that can adjuvant anti-cancer adoptive T-cell transfer (ACT) immunotherapy by promoting T-cell engraftment. However, the clinical applications of IL-2 in combination with ACT are greatly hindered by the… read more here.
Keywords: tumor; redox responsive; reactive cells; cell ... See more keywords
Frequency determination of breast tumor-reactive CD4 and CD8 T cells in humans: unveiling the antitumor immune response
Sign Up to like & getrecommendations! Published in 2019 at "OncoImmunology"
DOI: 10.1080/2162402x.2019.1607674
Abstract: ABSTRACT As cancer immunotherapy gains importance, the determination of a patient’s ability to react to his/her tumor is unquestionably relevant. Though the presence of T cells that recognize specific tumor antigens is well established, the… read more here.
Keywords: frequency; tumor reactive; reactive cells; tumor ... See more keywords
Bone marrow expands the repertoire of functional T cells targeting tumor-associated antigens in patients with resectable non-small-cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2019.1671762
Abstract: ABSTRACT The efficacy of cancer immunotherapy may be improved by increasing the number of circulating tumor-reactive T cells. The bone marrow is a priming site and reservoir for such T cells. The characteristics of bone… read more here.
Keywords: reactive cells; bone marrow; tumor; tumor reactive ... See more keywords
Preformed donor‐reactive T cells that persist after ABO desensitization predict severe T cell‐mediated rejection after living donor kidney transplantation – a retrospective study
Sign Up to like & getrecommendations! Published in 2019 at "Transplant International"
DOI: 10.1111/tri.13551
Abstract: Preformed donor‐reactive T cells are relatively resistant to standard immunosuppression and account for an increased incidence of T cell‐mediated rejection (TCMR) and inferior kidney allograft outcomes. We analyzed 150 living donor kidney transplant recipients (KTRs)… read more here.
Keywords: donor reactive; elispot; aboi ktrs; abo desensitization ... See more keywords
Sending B cells back in time
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DOI: 10.1126/science.366.6461.68-s
Abstract: Lymphocytes B-1 cells are a subset of self-reactive B cells that arise in early life. Precisely how and why the immune system permits the development of self-reactive B cells in neonates remains a mystery. By… read more here.
Keywords: self reactive; cells back; reactive cells; back time ... See more keywords
Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers
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DOI: 10.1126/science.abl5447
Abstract: The accurate identification of antitumor T cell receptors (TCRs) represents a major challenge for the engineering of cell-based cancer immunotherapies. By mapping 55 neoantigen-specific TCR clonotypes (NeoTCRs) from 10 metastatic human tumors to their single-cell… read more here.
Keywords: cell; metastatic human; reactive cells; tumor ... See more keywords
835 Structural difference caused by mutated residues is correlated with immunogenicity of neoantigens and specificity of reactive T cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0835
Abstract: Background Host T-cell response is limited to only a small fraction of nonsynonymous mutations; however, the molecular properties of those immunogenic neoantigens remain elusive. Methods Here, we interrogated the HLA class I ligandome of a… read more here.
Keywords: immunogenicity; reactive cells; structural difference; type ... See more keywords