Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments.
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DOI: 10.1021/acschembio.3c00034
Abstract: Sulfur(VI) fluorides (SFs) have emerged as valuable electrophiles for the design of "beyond-cysteine" covalent inhibitors and offer potential for expansion of the liganded proteome. Since SFs target a broad range of nucleophilic amino acids, they… read more here.
Keywords: reactive fragments; discovery using; efficient ligand; ligand discovery ... See more keywords