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   Articles with "reactive intermediates" as a keyword



Exploiting 3‐Methyleneisoindolinones as In Situ Generated Reactive Intermediates in the Synthesis of Tetrasubstituted Carbon Center

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recommendations! Published in 2025 at "Asian Journal of Organic Chemistry"

DOI: 10.1002/ajoc.202500562

Abstract: In this study, we describe the operationally simple construction of a tetrasubstituted carbon center utilizing in situ formation of 3‐methyleneisoindolinones as reactive intermediates. An acid‐catalyzed Meyer–Schuster rearrangement of isoindolinone‐based propargylic alcohols followed by an intermolecular… read more here.

Keywords: exploiting methyleneisoindolinones; carbon center; reactive intermediates; tetrasubstituted carbon ... See more keywords

Organic Peroxides in Aerosol: Key Reactive Intermediates for Multiphase Processes in the Atmosphere.

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recommendations! Published in 2023 at "Chemical reviews"

DOI: 10.1021/acs.chemrev.2c00430

Abstract: Organic peroxides (POs) are organic molecules with one or more peroxide (-O-O-) functional groups. POs are commonly regarded as chemically labile termination products from gas-phase radical chemistry and therefore serve as temporary reservoirs for oxidative… read more here.

Keywords: organic peroxides; reactive intermediates; key reactive; multiphase processes ... See more keywords

Characterization of reactive intermediates formation in dacomitinib metabolism and bioactivation pathways elucidation by LC-MS/MS: in vitro phase I metabolic investigation

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recommendations! Published in 2018 at "RSC Advances"

DOI: 10.1039/c8ra06709k

Abstract: Dacomitinib (DCB) is a second generation irreversible tyrosine kinase inhibitor (TKI) that is claimed to overcome the disadvantages of the resistance developed by the first line epidermal growth factor receptor (EGFR) TKIs. In the current… read more here.

Keywords: vitro phase; characterization reactive; bioactivation; reactive intermediates ... See more keywords
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Controlled Reactive Intermediates Enabling Facile Molecular Conjugation

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recommendations! Published in 2018 at "Bulletin of the Chemical Society of Japan"

DOI: 10.1246/bcsj.20180104

Abstract: Reliable methods to conjugate molecules using highly reactive substrates including strained cycloalkynes, azides, and thiophene S,S-dioxides, or short-lived intermediates such as arynes and 6- and ... read more here.

Keywords: intermediates enabling; facile molecular; reactive intermediates; controlled reactive ... See more keywords

Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach

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recommendations! Published in 2020 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s274018

Abstract: Background Ensartinib (ESB) is a novel anaplastic lymphoma kinase inhibitor (ALK) with additional activity against Abelson murine leukemia (ABL), met proto-oncogene (MET), receptor tyrosine kinase (AXL), and v-ros UR2 sarcoma virus oncogene homolog 1 (ROS1)… read more here.

Keywords: liver microsomes; drug; reactive intermediates; bioactivation ... See more keywords

Generation and Use of Reactive Intermediates Exploiting Flow Technology.

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recommendations! Published in 2025 at "Chimia"

DOI: 10.2533/chimia.2025.396

Abstract: Continuous flow technology has matured into a valuable and widely exploited technology across academic and industrial laboratories. The safe and on-demand generation of reactive intermediates using miniaturized flow set-ups is of particular value to realize… read more here.

Keywords: technology; generation use; flow technology; reactive intermediates ... See more keywords

Kinetic Behavior of Glutathione Transferases: Understanding Cellular Protection from Reactive Intermediates

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recommendations! Published in 2024 at "Biomolecules"

DOI: 10.3390/biom14060641

Abstract: Glutathione transferases (GSTs) are the primary catalysts protecting from reactive electrophile attack. In this review, the quantitative levels and distribution of glutathione transferases in relation to physiological function are discussed. The catalytic properties (random sequential)… read more here.

Keywords: protection; knowledge; reactive intermediates; glutathione transferases ... See more keywords
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Thiyl Radicals: Versatile Reactive Intermediates for Cyclization of Unsaturated Substrates

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recommendations! Published in 2020 at "Molecules"

DOI: 10.3390/molecules25133094

Abstract: Sulfur centered radicals are widely employed in chemical synthesis, in particular for alkene and alkyne hydrothiolation towards thioether bioconjugates. The steadfast radical chain process that enables efficient hydrothiolation has been explored in the context of… read more here.

Keywords: intermediates cyclization; versatile reactive; reactive intermediates; thiyl radicals ... See more keywords

Machine learning models predict calculation outcomes with the transferability necessary for computational catalysis

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recommendations! Published in 2022 at "Journal of chemical theory and computation"

DOI: 10.48550/arxiv.2203.01276

Abstract: Virtual high-throughput screening (VHTS) and machine learning (ML) have greatly accelerated the design of single-site transition-metal catalysts. VHTS of catalysts, however, is often accompanied with a high calculation failure rate and wasted computational resources due… read more here.

Keywords: reactive intermediates; dynamic classifier; machine learning; geometry ... See more keywords