Rapid screening and characterization of glutathione-trapped reactive metabolites using a polarity switch-based approach on a high-resolution quadrupole orbitrap mass spectrometer
Sign Up to like & getrecommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0814-8
Abstract: AbstractFormation of reactive metabolites that are capable to react with macromolecules could contribute to drug-induced toxicity. As part of early drug screening strategy to support small molecule structure-activity relationship analysis, glutathione (GSH) trapping is commonly… read more here.
Keywords: quadrupole orbitrap; mass; gsh conjugates; reactive metabolites ... See more keywords
The protein adduction derived from reactive metabolites of multiple furanoids in Cortex Dictamni-treated mice.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2022.01.001
Abstract: The association of herb medicine Cortex Dictamni (CD) with severe even fatal hepatotoxicity has been widely reported. Recently, we demonstrated that the metabolic activation of at least ten furanoids in CD was responsible for the… read more here.
Keywords: protein adduction; reactive metabolites; mice; liver injury ... See more keywords
EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: In Vivo and In Vitro Rat Studies.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00005
Abstract: Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of PTEN/Akt/FoxO3a pathway, which… read more here.
Keywords: inhibitor; pten akt; foxo3a pathway; cardiotoxicity ... See more keywords
Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1
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DOI: 10.1038/s41598-017-13054-3
Abstract: The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). Here we… read more here.
Keywords: capsaicin receptor; trpv1; receptor trpv1; acetaminophen ... See more keywords
Characterization of glutathione conjugates derived from reactive metabolites of seven silymarin isomers
Sign Up to like & getrecommendations! Published in 2018 at "Xenobiotica"
DOI: 10.1080/00498254.2018.1549340
Abstract: Abstract 1. Silymarin refers to a class of flavonoid lignans occurring in the fruits and seeds of the Silybum manalttlm (L). Gaertn, and is widely used in dietary supplements. 2. The main active ingredients of… read more here.
Keywords: glutathione conjugates; characterization glutathione; reactive metabolites; silymarin isomers ... See more keywords
Involvement of Reactive Metabolites of Diclofenac in Cytotoxicity in Sandwich-Cultured Rat Hepatocytes
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Toxicology"
DOI: 10.1177/1091581817700584
Abstract: Background and Objectives: Diclofenac (DIC) is metabolized to reactive metabolites such as diclofenac acyl-β-d-glucuronide (DIC-AG). It is possible that such reactive metabolites could cause tissue damage by formation of covalent protein adducts and other modification… read more here.
Keywords: covalent protein; dic dic; metabolites diclofenac; sandwich cultured ... See more keywords
Estradiol, Estrone and Ethinyl Estradiol Metabolism Studied by High Resolution LC-MS/MS Using Stable Isotope Labeling and Trapping of Reactive Metabolites
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12100931
Abstract: Biotransformation reactions that xenobiotics undergo during their metabolism are crucial for their proper excretion from the body, but can also be a source of toxicity, especially in the case of reactive metabolite formation. Unstable, reactive… read more here.
Keywords: metabolism; high resolution; estradiol estrone; ethinyl estradiol ... See more keywords