Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24265
Abstract: Extensive microglia reactivity has been well described in human and experimental temporal lobe epilepsy (TLE). To date, however, it is not clear whether and based on which molecular mechanisms microglia contribute to the development and… read more here.
Keywords: reactive microglia; factor; epilepsy; astrocyte dysfunction ... See more keywords
Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Neurology"
DOI: 10.1101/2022.08.16.504164
Abstract: Müller glia are a cellular source for neuronal regeneration in vertebrate retinas. However, the capacity for retinal regeneration varies widely across species. Understanding the mechanisms that regulate the reprogramming of Müller glia into progenitor cells… read more here.
Keywords: ller glia; damage; ller; reactive microglia ... See more keywords
Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-1712-0
Abstract: Background Astrocytes are the most abundant glial cells in a brain that mediate inflammatory responses and provide trophic support for neurons. We have previously disclosed that paroxetine, a common selective serotonin reuptake inhibitor, ameliorates LPS-induced… read more here.
Keywords: inflammatory responses; lps induced; primary astrocytes; microglia mediated ... See more keywords
Induction of NTPDase1/CD39 by Reactive Microglia and Macrophages Is Associated With the Functional State During EAE
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00410
Abstract: Purinergic signaling is critically involved in neuroinflammation associated with multiple sclerosis (MS) and its major inflammatory animal model, experimental autoimmune encephalomyelitis (EAE). Herein, we explored the expression of ectonucleoside triphosphate diphosphohydrolase1 (NTPDase1/CD39) in the spinal… read more here.
Keywords: microglia; reactive microglia; ntpdase1 cd39; eae ... See more keywords
Microglia in Cultured Porcine Retina: Qualitative Immunohistochemical Analyses of Reactive Microglia in the Outer Retina
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010871
Abstract: A late stage of several retinal disorders is retinal detachment, a complication that results in rapid photoreceptor degeneration and synaptic damages. Experimental retinal detachment in vivo is an invasive and complicated method performed on anesthetized… read more here.
Keywords: retinal detachment; microglia cultured; retina; porcine retina ... See more keywords
Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer’s Disease Mouse Model
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26092685
Abstract: Several genetic studies have identified a rare variant of triggering receptor expressed on myeloid cells 2 (TREM2) as a risk factor for Alzheimer’s disease (AD). However, findings on the effects of TREM2 on Aβ deposition… read more here.
Keywords: trem2; alzheimer disease; reactive microglia; pathology ... See more keywords