Reactive Oxygen Species–Activatable Liposomes Regulating Hypoxic Tumor Microenvironment for Synergistic Photo/Chemodynamic Therapies
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201905013
Abstract: Tumors have adapted various cellular antidotes and microenvironmental conditions to subsist against photodynamic therapy (PDT) and chemodynamic therapy (CDT). Here, the development of reactive oxygen species (ROS)‐activatable liposomes (RALP) for therapeutic enhancement by simultaneously addressing… read more here.
Keywords: tumor; tumor microenvironment; activatable liposomes; oxygen species ... See more keywords
Near‐Infrared Chemiluminescent Reporters for In Vivo Imaging of Reactive Oxygen and Nitrogen Species in Kidneys
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DOI: 10.1002/adfm.202003628
Abstract: Despite the superior sensitivity of chemiluminescence over fluorescence, most chemiluminescence reporters only emit visible light, and have low water solubility, making them poorly equipped for in vivo imaging applications. Herein two near‐infrared (NIR) chemiluminescent reporters… read more here.
Keywords: reactive oxygen; imaging reactive; near infrared; vivo imaging ... See more keywords
Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201704877
Abstract: Engineering functional nanomaterials with high therapeutic efficacy and minimum side effects has increasingly become a promising strategy for cancer treatment. Herein, a reactive oxygen species (ROS) enhanced combination chemotherapy platform is designed via a biocompatible… read more here.
Keywords: reactive oxygen; combination; oxygen species; metal ... See more keywords
Tumor Microenvironment-activated Reactive Oxygen Species Amplifier for Enzymatic Cascade Cancer Starvation/Chemodynamic /Immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202106010
Abstract: At present, some progresses have been made in the field of cancer theranostics based on nanocatalysts (NCs), but achieving the precisive theranostics in response to specific tumor microenvironment (TME) remains a major challenge. Herein, we… read more here.
Keywords: reactive oxygen; immunotherapy; starvation chemodynamic; cancer ... See more keywords
Sensitive Activatable Nanoprobes for Real‐Time Ratiometric Magnetic Resonance Imaging of Reactive Oxygen Species and Ameliorating Inflammation In Vivo
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DOI: 10.1002/adma.202109004
Abstract: Imaging‐guided real‐time monitoring of the treatment process of inflammatory diseases is important for the timely adjustment of treatment planning to lower unnecessary side effects and improve treatment outcomes. However, it is difficult to reflect the… read more here.
Keywords: magnetic resonance; reactive oxygen; inflammation; inflammation vivo ... See more keywords
Flexible Modulation of Cellular Activities with Cationic Photosensitizers: Insights of Alkyl Chain Length on Reactive Oxygen Species Antimicrobial Mechanisms.
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DOI: 10.1002/adma.202302943
Abstract: Cationic photosensitizers have good binding ability with negatively charged bacteria and fungi, exhibiting broad potential for use in antimicrobial photodynamic therapy (aPDT). However, cationic photosensitizers often display unsatisfactory transkingdom selectivity between mammalian cells and pathogens,… read more here.
Keywords: reactive oxygen; cellular activities; cationic photosensitizers; oxygen species ... See more keywords
Irradiation and parasitism affect the ability of larval hemocytes of Anastrepha obliqua for phagocytosis and the production of reactive oxygen species.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21953
Abstract: The development of the parasitoid Doryctobracon crawfordi (Viereck) (Hymenoptera: Braconidae) in Anastrepha obliqua (McQuart) (Diptera: Tephritidae) larvae is unviable in nature; however, if the host larva is irradiated at 160 Gy, the parasitoid develops and emerges… read more here.
Keywords: reactive oxygen; crawfordi; oxygen species; larvae ... See more keywords
Zinc cooperates with p53 to inhibit the activity of mitochondrial aconitase through reactive oxygen species accumulation
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DOI: 10.1002/cam4.2130
Abstract: Metabolic reprogramming is a central hallmark of cancer. Therefore, targeting metabolism may provide an effective strategy for identifying promising drug targets for cancer treatment. In prostate cancer, cells undergo metabolic transformation from zinc‐accumulating, citrate‐producing cells… read more here.
Keywords: reactive oxygen; oxygen species; zinc; prostate cancer ... See more keywords
Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy
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DOI: 10.1002/cmdc.202200185
Abstract: Photodynamic and sonodynamic therapy are therapies having great potential in the treatment of bacterial infections and cancer. Their background is associated with photo‐ and sonosensitizers ‐ substances that can be excited when exposed to light… read more here.
Keywords: reactive oxygen; state; oxygen species; therapy ... See more keywords
Imidazo[1,2‐a]pyridine Derivatives as AMPK Activators: Synthesis, Structure–Activity Relationships, and Regulation of Reactive Oxygen Species in Renal Fibroblasts
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202200696
Abstract: Adenosine 5′‐monophosphate activated protein kinase (AMPK) has emerged as a promising target for the discovery of drugs to treat diabetic nephropathy (DN). Herein, a series of imidazo[1,2‐a]pyridines were designed and synthesized. Among them, the active… read more here.
Keywords: reactive oxygen; imidazo pyridine; oxygen species; pyridine derivatives ... See more keywords
Reactive oxygen species in status epilepticus
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DOI: 10.1002/epi4.12691
Abstract: It has long been recognized that status epilepticus can cause considerable neuronal damage, and this has become one of its defining features. The mechanisms underlying this damage are less clear. Excessive activation of NMDA receptors… read more here.
Keywords: reactive oxygen; status epilepticus; oxygen species; species status ... See more keywords