N6-Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections
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DOI: 10.1128/mbio.03349-22
Abstract: Innate immunity is central to controlling pathogenic infections and maintaining the homeostasis of the host. In this study, we have revealed a novel mechanism regulating innate immune responses during viral and bacterial infections. ABSTRACT Mitogen-activated… read more here.
Keywords: protein ythdf2; reader protein; innate immune; protein ... See more keywords
N6-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication
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DOI: 10.1371/journal.ppat.1011305
Abstract: N6-methyladenosine (m6A) modification on viral RNAs has a profound impact on infectivity. m6A is also a highly pervasive modification for influenza viral RNAs. However, its role in virus mRNA splicing is largely unknown. Here, we… read more here.
Keywords: protein ythdc1; reader protein; virus; influenza virus ... See more keywords
The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver
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DOI: 10.3389/fimmu.2023.1119750
Abstract: ING5 is a component of KAT6A and KAT7 histone lysine acetylation protein complexes. ING5 contains a PHD domain that binds to histone H3 lysine 4 when it is trimethylated, and so functions as a ‘reader’… read more here.
Keywords: chromatin reader; cell; reader protein; hematopoiesis ... See more keywords