Biological role and mechanism of chromatin readers in plants.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2021.102008
Abstract: Epigenetic modifications are important gene regulatory mechanisms conserved in plants, animals, and fungi. Chromatin reader domains are protein-protein/DNA interaction modules acting within the chromatin-modifying complex to function as molecular interpreters of the epigenetic code. Understanding… read more here.
Keywords: reader proteins; reader; role mechanism; chromatin ... See more keywords
Identification of N6-methyladenosine reader proteins.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2017.04.019
Abstract: The reversible N6-methyladenosine (m6A) modification of eukaryotic messenger RNAs (mRNAs) is a widespread regulatory mechanism that impacts every step in the mRNA life cycle. The effect of m6A on mRNA fate depends on the binding… read more here.
Keywords: reader proteins; reader; methyladenosine; m6a reader ... See more keywords
Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b05012
Abstract: Post-transcriptional gene expression regulation of RNA has emerged as a key factor that controls mammalian protein production. RNA trafficking, translation efficiency, and stability are all controlled at the transcript level. For example, in addition to… read more here.
Keywords: reader proteins; targeted m6a; reader; rna ... See more keywords
Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04294k
Abstract: The flexible N-terminal histone tails are a subject of numerous posttranslational modifications, including methylation. We report development of stapled histone peptides bearing trimethyllysine as ligands for epigenetic reader proteins. Stronger or weaker binding affinities have… read more here.
Keywords: epigenetic reader; histone; recognition stapled; reader proteins ... See more keywords
Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25081918
Abstract: Gaining a fundamental insight into the biomolecular recognition of posttranslationally modified histones by epigenetic reader proteins is of crucial importance to understanding the regulation of the activity of human genes. Here, we seek to establish… read more here.
Keywords: trimethyllysine; reader proteins; reader; molecular recognition ... See more keywords