Novel Insights Into Small Open Reading Frame‐Encoded Micropeptides in Glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology International"
DOI: 10.1002/cbin.70093
Abstract: Glioblastoma is the most aggressive type of brain tumor, with a dismal prognosis, highlighting the urgent need for novel biomarkers and therapeutic targets. Recent advances in transcriptomics and proteomics have revealed the critical role of… read more here.
Keywords: open reading; encoded micropeptides; reading frame; small open ... See more keywords
Expression of L1 retrotransposon open reading frame protein 1 (L1ORF1p) in gynecologic cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2019.06.001
Abstract: LINE-1 (L1) retrotransposons are mobile genetic elements capable of "copy-and-pasting" their own sequences into random genomic loci and one of the proteins it uses to achieve mobility is LINE-1 open reading frame 1 protein (L1ORF1p).… read more here.
Keywords: frame protein; reading frame; l1orf1p expression; expression ... See more keywords
Transcription-associated mutational pressure in the Parvovirus B19 genome: Reactivated genomes contribute to the variability of viral populations.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.09.019
Abstract: In this study we used non-overlapping parts of the two long open reading frames coding for nonstructural (NS) and capsid (VP) proteins of all available sequences of the Parvovirus B19 subgenotype 1a genome and found… read more here.
Keywords: transcription; mutational pressure; parvovirus b19; reading frame ... See more keywords
Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemia/reperfused isolated rat hearts
Sign Up to like & getrecommendations! Published in 2020 at "Peptides"
DOI: 10.1016/j.peptides.2019.170192
Abstract: The novel peptide dwarf open reading frame (DWORF), highly conserved across species and expressed almost exclusively in cardiac ventricular muscle, may play a role in cardiac physiology and pathophysiology. The effect of direct administration of… read more here.
Keywords: rat hearts; reading frame; effects dworf; dwarf open ... See more keywords
Introducing COCOS: codon consequence scanner for annotating reading frame changes induced by stop-lost and frame shift variants
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btw820
Abstract: Abstract Summary Reading frame altering genomic variants can impact gene expression levels and the structure of protein products, thus potentially inducing disease phenotypes. Current annotation approaches report the impact of such variants in the context… read more here.
Keywords: reading frame; frame; stop lost; cocos ... See more keywords
Implication of nucleotides near the 3′ end of 16S rRNA in guarding the translational reading frame
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae143
Abstract: Abstract Loss of the translational reading frame leads to misincorporation and premature termination, which can have lethal consequences. Based on structural evidence that A1503 of 16S rRNA intercalates between specific mRNA bases, we tested the… read more here.
Keywords: 16s rrna; reading frame; translational reading;
Intragenic duplication disrupting the reading frame of MFSD8 in Small Swiss Hounds with neuronal ceroid lipofuscinosis.
Sign Up to like & getrecommendations! Published in 2024 at "Animal genetics"
DOI: 10.1111/age.13485
Abstract: Neuronal ceroid lipofuscinosis (NCL) represents a heterogenous group of lysosomal storage diseases resulting in progressive neurodegeneration. We investigated two Small Swiss Hound littermates that showed progressive ataxia and loss of cognitive functions and vision starting… read more here.
Keywords: small swiss; reading frame; duplication; swiss hounds ... See more keywords
Triple Intergenotype Recombination of Human Astrovirus 5, Human Astrovirus 8, and Human Astrovirus 1 in the Open Reading Frame 1a, Open Reading Frame 1b, and Open Reading Frame 2 Regions of the Human Astrovirus Genome
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04888-22
Abstract: Recombination is one of the mechanisms that plays a crucial role in the genetic diversity and evolution of HAstV. We wished to investigate the emergence of HAstV recombinant strains and to analyze the whole-genome sequences… read more here.
Keywords: recombination; reading frame; recombinant strains; human astrovirus ... See more keywords
The Bacillus subtilis open reading frame ysgA encodes the SPOUT methyltransferase RlmP forming 2'-O-methylguanosine at position 2553 in the A-loop of 23S rRNA.
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079131.122
Abstract: A previous bioinformatic analysis predicted that the ysgA open reading frame of Bacillus subtilis encodes an RNA methyltransferase of the SPOUT superfamily. Here we show that YsgA is the 2'-O-methyltransferase that targets position G2553 (Escherichia… read more here.
Keywords: reading frame; ysga; 23s rrna; methyltransferase ... See more keywords
Open reading frame dominance indicates protein‐coding potential of RNAs
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202154321
Abstract: Recent studies have identified numerous RNAs with both coding and noncoding functions. However, the sequence characteristics that determine this bifunctionality remain largely unknown. In the present study, we develop and test the open reading frame… read more here.
Keywords: coding noncoding; orf dominance; reading frame; dominance ... See more keywords
Walking alone milestone combined reading-frame rule improves early prediction of Duchenne muscular dystrophy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.985878
Abstract: Objective To explore the potential of walking alone milestone combined reading-frame rule to improve the early diagnosis of Duchenne muscular dystrophy (DMD). Method To retrospectively describe the genotype and phenotype of Duchenne and Becker muscular… read more here.
Keywords: reading; reading frame; walking alone; frame rule ... See more keywords