A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24575-x
Abstract: Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation termination at PTCs. Poor efficacy of… read more here.
Keywords: readthrough; translational readthrough; small molecule; induces translational ... See more keywords
Aminoglycoside-mediated promotion of translation readthrough occurs through a non-stochastic mechanism that competes with translation termination
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx409
Abstract: Attempts have been made to treat nonsense-associated genetic disorders by chemical agents and hence an improved mechanistic insight into the decoding of readthrough signals is essential for the identification and characterisation of factors for the… read more here.
Keywords: readthrough; mechanism; occurs non; mediated promotion ... See more keywords
A Stem-Loop Structure in Potato Leafroll Virus Open Reading Frame 5 (ORF5) Is Essential for Readthrough Translation of the Coat Protein ORF Stop Codon 700 Bases Upstream
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01544-17
Abstract: ABSTRACT Translational readthrough of the stop codon of the capsid protein (CP) open reading frame (ORF) is used by members of the Luteoviridae to produce their minor capsid protein as a readthrough protein (RTP). The… read more here.
Keywords: protein; readthrough; structure; codon ... See more keywords
A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay
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DOI: 10.1371/journal.pone.0173980
Abstract: The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing premature termination codons, limiting the expression of potentially deleterious truncated proteins. This activity positions the pathway as a regulator of the severity of genetic diseases caused… read more here.
Keywords: readthrough; system; translational readthrough; analysis ... See more keywords
Complex and simple translational readthrough signals in pea enation mosaic virus 1 and potato leafroll virus, respectively
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DOI: 10.1371/journal.ppat.1010888
Abstract: Different essential viral proteins are translated via programmed stop codon readthrough. Pea enation mosaic virus 1 (PEMV1) and potato leafroll virus (PLRV) are related positive-sense RNA plant viruses in the family Solemoviridae, and are type… read more here.
Keywords: structure; pea enation; readthrough; enation mosaic ... See more keywords
Emerging Personalized Opportunities for Enhancing Translational Readthrough in Rare Genetic Diseases and Beyond
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DOI: 10.3390/ijms24076101
Abstract: Nonsense mutations trigger premature translation termination and often give rise to prevalent and rare genetic diseases. Consequently, the pharmacological suppression of an unscheduled stop codon represents an attractive treatment option and is of high clinical… read more here.
Keywords: genetic diseases; stop codon; readthrough; rare genetic ... See more keywords