Reagent-Controlled Regiodivergent Annulations of Achmatowicz Products with Vinylogous Nucleophiles: Synthesis of Bicyclic Cyclopenta[b]pyrans and 8-Oxabicyclo[3.2.1]octane Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03127
Abstract: Two reagent-controlled regiodivergent annulation protocols for Achmatowicz products with vinylogous nucleophiles have been developed, which furnished a series of bicyclic cyclopenta[b]pyrans and 8-oxabicyclo[3.2.1]octane derivatives in 28-90% yields. Plausible mechanisms were proposed to involve either Pd-catalyzed… read more here.
Keywords: bicyclic cyclopenta; products vinylogous; controlled regiodivergent; achmatowicz products ... See more keywords
Reagent-controlled regiodivergent ring expansions of steroids
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DOI: 10.1038/s41467-018-03248-2
Abstract: Ring expansion provides a powerful way of introducing a heteroatom substituent into a carbocyclic framework. However, such reactions are often limited by the tendency of a given substrate to afford only one of the two… read more here.
Keywords: late stage; reagent controlled; ring expansion; natural products ... See more keywords