Metal-Free Construction of the C(sp3)-CF3 Bond: Trifluoromethylation of Hydrazones with Togni's Reagent under Mild Conditions.
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DOI: 10.1021/acs.orglett.9b02072
Abstract: A metal-free trifluoromethylation of hydrazones with Togni's reagent under mild conditions was developed. Various functional groups including ester, methoxy, dimethoxy, nitro, halogen, and heterocyclic compounds were tolerated. This simple and green strategy provides a practical… read more here.
Keywords: mild conditions; togni reagent; trifluoromethylation hydrazones; metal free ... See more keywords