Methylene Thiazolidinediones as Alkylation Reagents in Catalytic C-H Functionalization: Rapid Access to Glitazones.
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DOI: 10.1021/acs.orglett.2c03677
Abstract: The straightforward and rapid incorporation of a thiazolidinedione scaffold into prefunctionalized (hetero)aromatic compounds is in demand for the development of antidiabetic glitazones and other pharmaceuticals. Herein, we report the unprecedented N- and O-directed C-H alkylation… read more here.
Keywords: alkylation; reagents catalytic; catalytic functionalization; thiazolidinediones alkylation ... See more keywords