Asymmetric addition of Grignard reagents to ketones: culmination of the ligand-mediated methodology allows modular construction of chiral tertiary alcohols
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DOI: 10.1039/d1sc06350b
Abstract: A new class of biaryl chiral ligands derived from 1,2-diaminocyclohexane (1,2-DACH) has been designed to enable the asymmetric addition of aliphatic and, for the first time, aromatic Grignard reagents to ketones for the preparation of… read more here.
Keywords: grignard reagents; methodology; asymmetric addition; reagents ketones ... See more keywords