Cu-Catalyzed Conjugate Addition of Grignard Reagents to Thiochromones: An Enantioselective Pathway for Accessing 2-Alkylthiochromanones
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DOI: 10.1055/s-0037-1610225
Abstract: The enantioselective incorporation of alkyl groups in thiochromones was realized for the first time by a Cu/(R,S)-PPF-P t Bu2-catalyzed conjugate addition of Grignard reagents to thiochromones. With this method, a series of 2-methylthiochromanones were obtained… read more here.
Keywords: reagents thiochromones; grignard reagents; conjugate addition; catalyzed conjugate ... See more keywords