Realgar (α-As4S4) Treats Myelodysplasic Syndromes through Reducing DNA Hypermethylation
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-020-3263-8
Abstract: DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes (MDS). Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes, inducing gene silencing. Realgar (α-As4S4)… read more here.
Keywords: realgar; medicine; realgar as4s4; dna hypermethylation ... See more keywords
Dissolution of realgar by Acidithiobacillus ferrooxidans in the presence and absence of zerovalent iron: Implications for remediation of iron-deficient realgar tailings.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.05.192
Abstract: Realgar (As4S4)-rich tailings are iron-deficient arsenical mine wastes. The mechanisms and products of the dissolution of realgar by Acidithiobacillus ferrooxidans (A. ferrooxidans) in the presence (0.2 g and 2 g) and absence of zerovalent iron (ZVI) are investigated… read more here.
Keywords: dissolution realgar; zvi; iron deficient; realgar ... See more keywords
Fatal acute arsenic poisoning by external use of realgar: Case report and 30 years literature retrospective study in China.
Sign Up to like & getrecommendations! Published in 2019 at "Forensic science international"
DOI: 10.1016/j.forsciint.2019.03.012
Abstract: Realgar (arsenic sulfide) is widely used in combination with other herbs as Chinese patent medicine to treat a variety of diseases in China. As a mineral arsenic, its mild toxicity was also well known. Longtime… read more here.
Keywords: use realgar; realgar; medicine; fatal acute ... See more keywords
Combination of LC/MS and GC/MS based metabolomics to study the hepatotoxic effect of realgar nanoparticles in rats.
Sign Up to like & getrecommendations! Published in 2017 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(17)30098-5
Abstract: Realgar nanoparticles (NPs) are increasingly used as therapeutic agents for their enhanced anti-proliferation effect and cytotoxicity on cancer cells. However, the alteration of particle size may enhance biological reactivity as well as toxicity. A LC/MS… read more here.
Keywords: realgar nanoparticles; realgar nps; effect; hepatotoxicity ... See more keywords
(-)-Epigallocatechin-3-gallate encapsulated realgar nanoparticles exhibit enhanced anticancer therapeutic efficacy against acute promyelocytic leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Drug Delivery"
DOI: 10.1080/10717544.2019.1672830
Abstract: Abstract Realgar and (-)-Epigallocatechin-3-gallate (EGCG) are natural medicines that inhibit cancer cell growth, resulting in inhibition of formation and development of tumors. The anticancer effects of realgar and EGCG were greatly improved following formulation as… read more here.
Keywords: egcg rnps; epigallocatechin gallate; egcg; realgar ... See more keywords
Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent
Sign Up to like & getrecommendations! Published in 2017 at "Biological Research"
DOI: 10.1186/s40659-017-0122-y
Abstract: Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetra-sulfide (As4S4). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted… read more here.
Keywords: antitumor mechanism; agent; methodology; realgar bioleaching ... See more keywords
Characterization and Comparative Physico-Chemical Studies of Manahshila (Traditionally Used Arsenic Mineral) and the Corresponding Polymorphs of Realgar (As 4 S 4 )
Sign Up to like & getrecommendations! Published in 2017 at "Current Science"
DOI: 10.18520/cs/v112/i09/1936-1941
Abstract: This communication presents characterization and comparison of the physico-chemical properties of different varieties of Manahshila with the corresponding polymorphs of realgar. Three varieties of Manahshila have been described in Ayurveda, viz. Shyamangi, Kanavirak and Khandakhya;… read more here.
Keywords: corresponding polymorphs; polymorphs realgar; realgar; characterization ... See more keywords
Multifunctional Nano-Realgar Hydrogel for Enhanced Glioblastoma Synergistic Chemotherapy and Radiotherapy: A New Paradigm of an Old Drug
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s394377
Abstract: Purpose Realgar, as a kind of traditional mineral Chinese medicine, can inhibit multiple solid tumor growth and serve as an adjuvant drug in cancer therapy. However, the extremely low solubility and poor body absorptive capacity… read more here.
Keywords: nano realgar; realgar hydrogel; nra gel; realgar ... See more keywords
Arsenic-Related Health Risk Assessment of Realgar-Containing NiuHuangJieDu Tablets in Healthy Volunteers Po Administration
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.761801
Abstract: Realgar, an arsenic-containing traditional Chinese medicine of As2S2, has significant therapeutic effects for hundreds of years. NiuHuangJieDu tablets (NHJDT) is one of the most commonly prescribed realgar-containing preparations for the treatment of sore throat, swelling,… read more here.
Keywords: health; niuhuangjiedu tablets; realgar containing; realgar ... See more keywords
Realgar-induced KRAS mutation lung cancer cell death via KRAS/Raf/MAPK mediates ferroptosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5447
Abstract: KRAS is a biomarker for non-small cell lung cancer-targeted therapy, but there is currently no effective KRAS-targeting medication. Realgar is an impelling anti-cancer drug, however its significance in KRAS mutant lung cancer is uncertain. According… read more here.
Keywords: lung cancer; kras mutant; realgar; cells treated ... See more keywords