Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin
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DOI: 10.1038/leu.2016.165
Abstract: To address the poor prognosis of mixed lineage leukemia (MLL)-rearranged infant acute lymphoblastic leukemia (iALL), we generated a panel of cell lines from primary patient samples and investigated cytotoxic responses to contemporary and novel Food… read more here.
Keywords: infant acute; lymphoblastic leukemia; rearranged infant; acute lymphoblastic ... See more keywords
Preclinical efficacy of gemcitabine in MLL-rearranged infant acute lymphoblastic leukemia
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DOI: 10.1038/s41375-020-0895-9
Abstract: The treatment of children diagnosed with acute lymphoblastic leukemia (ALL) has improved significantly over recent decades, with 5-year event-free survival (EFS) approaching 85% [1]. However, 5-year EFS for infants diagnosed at less than 1 year… read more here.
Keywords: mll rearranged; rearranged infant; acute lymphoblastic; lymphoblastic leukemia ... See more keywords
Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.
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DOI: 10.1038/s41591-022-01720-7
Abstract: KMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia (B-ALL) using bulk messenger RNA (mRNA) meta-analysis and examination of single… read more here.
Keywords: kmt2a rearranged; leukemia; state; cell ... See more keywords