Synthesis of Trisubstituted Oxazoles via Aryne Induced [2,3] Sigmatropic Rearrangement-Annulation Cascade.
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DOI: 10.1021/acs.orglett.2c01379
Abstract: A transition-metal-free, [2,3] sigmatropic rearrangement-annulation cascade of 2-substituted thio/amino acetonitriles with arynes allowing the synthesis of 2,4,5-trisubstituted oxazoles under mild conditions has been demonstrated. The key sulfur/nitrogen ylides were generated by the initial S/N arylation… read more here.
Keywords: synthesis trisubstituted; rearrangement annulation; annulation cascade; rearrangement ... See more keywords