Synthesis of Azetidine Nitrones and Exomethylene Oxazolines through a Copper(I)-Catalyzed 2,3-Rearrangement and 4π-Electrocyclization Cascade Strategy.
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DOI: 10.1021/acs.orglett.2c03156
Abstract: A variety of azetidine nitrones are prepared in moderate to good yields through copper(I) combined with 2-aminopyridine to catalyze skeletal rearrangement of O-propargylic oximes. Mechanistic studies reveal that the reaction undergoes a copper(I)-catalyzed tandem [2,3]-rearrangement,… read more here.
Keywords: nitrones exomethylene; azetidine nitrones; azetidine; exomethylene oxazolines ... See more keywords