Two Dynamical Regimes of the Substrate Radical Rearrangement Reaction in B12-Dependent Ethanolamine Ammonia-Lyase Resolve Contributions of Native Protein Configurations and Collective Configurational Fluctuations to Catalysis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00294
Abstract: The kinetics of the substrate radical rearrangement reaction step in B12-dependent ethanolamine ammonia-lyase (EAL) from Salmonella typhimurium are measured over a 92 K temperature range. The observed first-order rate constants display a piecewise-continuous Arrhenius dependence,… read more here.
Keywords: rearrangement reaction; substrate radical; radical rearrangement; reaction ... See more keywords
Semisynthesis of (-)-Bufospirostenin A Enabled by Photosantonin Rearrangement Reaction.
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DOI: 10.1021/jacs.1c12395
Abstract: An enantioselective semisynthesis of (-)-bufospirostenin A is described. The key steps in the synthesis involve use of our proposed biomimetic and diastereoselective photosantonin rearrangement reaction for construction of the 5/7 bicyclic motif, and a Co-catalyzed… read more here.
Keywords: reaction; semisynthesis bufospirostenin; photosantonin rearrangement; rearrangement reaction ... See more keywords
Palladium-catalyzed rearrangement reaction to access 1-phenanthrol derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00392a
Abstract: This manuscript describes an unusual Pd-catalyzed rearrangement reaction. It provides efficient access to 1-phenanthrol derivatives using allyloxy-tethered aryl iodides. This rearrangement process involves the cleavage of a C-I bond, a C-O bond and C-H bonds,… read more here.
Keywords: catalyzed rearrangement; access phenanthrol; phenanthrol derivatives; rearrangement reaction ... See more keywords