An Alkyne-Isocyanide Cycloaddition/Boulton-Katritzky Rearrangement/Ring Expansion Reaction: Access to 9-Deazaguanines.
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DOI: 10.1021/acs.orglett.3c00575
Abstract: An alkyne-isocyanide [3 + 2] cycloaddition followed by a Boulton-Katritzky rearrangement and a ring expansion is demonstrated. Different from the typical Boulton-Katritzky rearrangement, which forms five-membered ring products, the rearrangement-ring expansion method provides a mild,… read more here.
Keywords: boulton katritzky; ring expansion; katritzky rearrangement; rearrangement ring ... See more keywords