Neoadjuvant Chemotherapy or Endocrine Therapy for Invasive Ductal Carcinoma of the Breast With High Hormone Receptor Positivity and Human Epidermal Growth Factor Receptor 2 Negativity
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.1785
Abstract: Key Points Question Is neoadjuvant endocrine therapy (NET) an alternative treatment for neoadjuvant chemotherapy (NACT) in patients with invasive ductal carcinoma (IDC) of the breast who have strong hormone receptor (HR) positivity and human epidermal… read more here.
Keywords: endocrine therapy; hormone receptor; invasive ductal; ductal carcinoma ... See more keywords
Association of Adjuvant Hormone Therapy Timing With Overall Survival Among Patients With Hormone Receptor–Positive Human Epidermal Growth Factor Receptor-2–Negative Early Breast Cancer Without Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.45934
Abstract: Key Points Question Is delayed adjuvant hormone therapy (AHT) associated with reduced survival in patients with hormone receptor–positive breast cancer? Findings In this cohort study of 144 103 US patients with hormone receptor–positive/human epidermal growth factor… read more here.
Keywords: survival; receptor positive; hormone receptor; breast cancer ... See more keywords
Appropriate Use of Antiemetics to Prevent Chemotherapy-Induced Nausea and Vomiting.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2016.2616
Abstract: Overuse of low-value oncology services has received increasing attention recently.1 National campaigns, such as “Choosing Wisely,” have prompted medical specialty societies to identify areas for reducing use of low-value services. The use of antiemetic drugs… read more here.
Keywords: chemotherapy; risk; use; receptor ... See more keywords
Association of Circulating Tumor Cells With Late Recurrence of Estrogen Receptor–Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.2574
Abstract: Importance Late recurrence 5 or more years after diagnosis accounts for at least one-half of all cases of recurrent hormone receptor–positive breast cancer. Objective To determine whether the presence of circulating tumor cells (CTCs) in… read more here.
Keywords: receptor; analysis; recurrence; breast cancer ... See more keywords
Safety, Tolerability, and Potential Clinical Activity of a Glucocorticoid-Induced TNF Receptor-Related Protein Agonist Alone or in Combination With Nivolumab for Patients With Advanced Solid Tumors: A Phase 1/2a Dose-Escalation and Cohort-Expansion Clinical Trial.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2019.3848
Abstract: Importance Multiple immunostimulatory agonist antibodies have been clinically tested in solid tumors to evaluate the role of targeting glucocorticoid-induced tumor necrosis factor (TNF) receptor-related protein in anticancer treatments. Objective To evaluate the safety and activity… read more here.
Keywords: combination; solid tumors; safety; bms 986156 ... See more keywords
An Overview of Clinical Development of Agents for Metastatic or Advanced Breast Cancer Without ERBB2 Amplification (HER2-Low).
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.4175
Abstract: Importance Erb-b2 receptor tyrosine kinase 2 (ERBB2; formerly HER2 [human epidermal growth factor receptor 2]) is an important prognostic and predictive factor in breast cancer. Anti-ERBB2 therapies have improved outcomes in ERBB2-positive breast cancer. However,… read more here.
Keywords: breast cancer; erbb2 low; cancer; receptor ... See more keywords
Efficacy of Alternative Dose Regimens of Exemestane in Postmenopausal Women With Stage 0 to II Estrogen Receptor-Positive Breast Cancer: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2023.0089
Abstract: Importance Successful therapeutic cancer prevention requires definition of the minimal effective dose. Aromatase inhibitors decrease breast cancer incidence in high-risk women, but use in prevention and compliance in adjuvant settings are hampered by adverse events.… read more here.
Keywords: times weekly; daily times; breast cancer; receptor ... See more keywords
The coxsackievirus and adenovirus receptor: virological and biological beauty
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DOI: 10.1002/1873-3468.13794
Abstract: The coxsackievirus and adenovirus receptor (CAR) is an essential multifunctional cellular protein that is only beginning to be understood. CAR serves as a receptor for many adenoviruses, human group B coxsackieviruses, swine vesicular disease virus,… read more here.
Keywords: receptor virological; adenovirus receptor; receptor; virological biological ... See more keywords
Activation of P2X4 receptors induces an increase in the area of the extracellular region and a decrease in receptor mobility
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DOI: 10.1002/1873-3468.13942
Abstract: The P2X4 receptor (P2X4R) is an ATP‐gated cation channel. Here, we used fast‐scan atomic force microscopy (AFM) to visualize changes in the structure and mobility of individual P2X4Rs in response to activation. P2X4Rs were purified… read more here.
Keywords: extracellular region; mobility; activation; area extracellular ... See more keywords
Dynamics and electrostatics define an allosteric druggable site within the receptor‐binding domain of SARS‐CoV‐2 spike protein
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DOI: 10.1002/1873-3468.14038
Abstract: The pathogenesis of the SARS‐CoV‐2 virus initiates through recognition of the angiotensin‐converting enzyme 2 (ACE2) receptor of the host cells by the receptor‐binding domain (RBD) located at the spikes of the virus. Here, using molecular… read more here.
Keywords: binding domain; electrostatics; receptor; sars cov ... See more keywords
Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor.
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DOI: 10.1002/1873-3468.14292
Abstract: Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signaling receptor glycoprotein 130 (gp130). The structural details as well… read more here.
Keywords: staphylococcal enterotoxin; gp130; cytokine; human gp130 ... See more keywords