Development of an Orally Active Small-Molecule Inhibitor of Receptor Activator of Nuclear Factor-κB Ligand.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00081
Abstract: Receptor activator of nuclear factor-κB (RANK) and its ligand, RANKL, play pivotal roles in bone remodeling. The monoclonal antibody denosumab successfully inhibited the maturation of osteoclasts (OCs) by binding to RANKL in the clinic. We… read more here.
Keywords: nuclear factor; small molecule; receptor activator; activator nuclear ... See more keywords
Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Receptor Activator of Nuclear Factor-κB (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b02027
Abstract: Targeting RANKL/RANK offers the possibility of developing novel therapeutic approaches to treat bone metabolic diseases. Multiple efforts have been made to inhibit RANKL. For example, marketed monoclonal antibody drug Denosumab could inhibit the maturation of… read more here.
Keywords: receptor activator; activator nuclear; nuclear factor; rankl ... See more keywords
Commentary on the effects of receptor activator of nuclear factor‐B ligand inhibition on bone mass and muscle strength
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13165
Abstract: The pathophysiology of osteoporosis and sarcopenia. read more here.
Keywords: commentary effects; receptor activator; activator nuclear; factor ligand ... See more keywords
Differential expression of periostin, sclerostin, receptor activator of nuclear factor‐&kgr;B, and receptor activator of nuclear factor‐&kgr;B ligand genes in severe chronic periodontitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Investigative and Clinical Dentistry"
DOI: 10.1111/jicd.12369
Abstract: AIM The aim of the present study was to determine and compare the expression profile of periostin (POSTN), sclerostin (SOST), receptor activator nuclear factor-κB (RANK), and RANK ligand (RANKL) genes in gingival tissue samples collected… read more here.
Keywords: receptor activator; activator nuclear; expression; severe chronic ... See more keywords
Isofraxidin Inhibits Receptor Activator of Nuclear Factor-κB Ligand–Induced Osteoclastogenesis in Bone Marrow–Derived Macrophages Isolated from Sprague–Dawley Rats by Regulating NF-κB/NFATc1 and Akt/NFATc1 Signaling Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Cell Transplantation"
DOI: 10.1177/0963689721990321
Abstract: Osteoporosis is a common bone disease that is characterized by decreased bone mass and fragility fractures. Isofraxidin is a hydroxy coumarin with several biological and pharmacological activities including an anti-osteoarthritis effect. However, the role of… read more here.
Keywords: receptor activator; activator nuclear; bone; factor ligand ... See more keywords
Evocalcet with vitamin D receptor activator treatment for secondary hyperparathyroidism
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DOI: 10.1371/journal.pone.0262829
Abstract: This ad hoc analysis of a previously conducted phase 3 head-to-head comparison study of evocalcet and cinacalcet in secondary hyperparathyroidism patients undergoing maintenance hemodialysis evaluated the efficacy and safety of combined once-daily oral evocalcet and… read more here.
Keywords: vitamin receptor; corrected calcium; receptor activator;
The Expression of Matrix Metalloproteinases in Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL)-expressing Cancer of Apocrine Origin.
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DOI: 10.21873/anticanres.12198
Abstract: Primary cutaneous apocrine carcinoma (PCAC) is a rare and highly aggressive tumor entity. Since there is no conventional therapy for advanced PCAC, exploratory treatments are sometimes used. As we previously reported, receptor activator of nuclear… read more here.
Keywords: receptor activator; activator nuclear; ligand; apocrine ... See more keywords
Tetrabromobisphenol A Promotes the Osteoclastogenesis of RAW264.7 Cells Induced by Receptor Activator of NF-kappa B Ligand In Vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Korean Medical Science"
DOI: 10.3346/jkms.2019.34.e267
Abstract: Background Tetrabromobisphenol A (TBBPA), one of the most widely used brominated flame-retardants, is a representative persistent organic pollutants group. Studies on TBBPA toxicity have been conducted using various target cells; however, few studies have investigated… read more here.
Keywords: receptor activator; tetrabromobisphenol; kappa ligand; vitro ... See more keywords
Roles of osteoprotegerin in endocrine and metabolic disorders through receptor activator of nuclear factor kappa-B ligand/receptor activator of nuclear factor kappa-B signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1005681
Abstract: Endocrine and metabolic diseases show increasing incidence and high treatment costs worldwide. Due to the complexity of their etiology and mechanism, therapeutic strategies are still lacking. Osteoprotegerin (OPG), a member of the tumor necrosis factor… read more here.
Keywords: nuclear factor; receptor activator; activator nuclear; factor ... See more keywords
Decreased level of soluble receptor activator of nuclear factor-κβ ligand (sRANKL) in overweight and obese children
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.963467
Abstract: Introduction Childhood obesity contributes to the development of cardiovascular diseases. The molecular pathway – receptor activator of nuclear factor-κβ ligand (RANKL), its receptor RANK and osteoprotegerin (OPG) - takes part not only in bone metabolism… read more here.
Keywords: opg srankl; receptor activator; obese children; overweight obese ... See more keywords
Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00234
Abstract: C-reactive protein (CRP) is an established marker of rheumatoid arthritis (RA) but with ill-defined actions in the pathogenesis. Here, we show that CRP regulates the differentiation of osteoclasts, a central mediator of joint inflammation and… read more here.
Keywords: osteoclast differentiation; reactive protein; receptor activator; differentiation ... See more keywords