Association of Prescription Co-payment With Adherence to Glucagon-Like Peptide-1 Receptor Agonist and Sodium-Glucose Cotransporter-2 Inhibitor Therapies in Patients With Heart Failure and Diabetes
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.16290
Abstract: This cohort study compares rates of 1-year adherence to glucagon-like peptide-1 receptor agonist or sodium-glucose cotransporter 2 inhibitor therapies by co-payment level among US adults with type 2 diabetes and/or heart failure. read more here.
Keywords: agonist sodium; peptide receptor; glucagon like; adherence glucagon ... See more keywords
A CXCR4 receptor agonist strongly stimulates axonal regeneration after damage
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50926
Abstract: To test whether the signaling axis CXCL12α‐CXCR4 is activated upon crush/cut of the sciatic nerve and to test the activity of NUCC‐390, a new CXCR4 agonist, in promoting nerve recovery from damage. read more here.
Keywords: strongly stimulates; receptor agonist; cxcr4 receptor; damage ... See more keywords
Remyelination in humans due to a retinoid‐X receptor agonist is age‐dependent
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51595
Abstract: Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that bexarotene, a putatively remyelinating retinoid‐X receptor agonist, shortened the visual evoked… read more here.
Keywords: remyelination; age; retinoid receptor; remyelination humans ... See more keywords
Conjugation of a Toll‐Like Receptor Agonist to Glycans of an HIV Native‐Like Envelope Trimer Preserves Neutralization Epitopes
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200236
Abstract: Small molecule adjuvants are attractive for enhancing broad protection and durability of immune responses elicited by subunit vaccines. Covalent attachment of an adjuvant to an immunogen is particularly attractive because it simultaneously delivers both entities… read more here.
Keywords: envelope trimer; native like; toll like; like receptor ... See more keywords
Evaluation of the Pharmacokinetics of Felcisetrag (TAK‐954), a 5‐HT4 Receptor Agonist, in the Presence and Absence of Itraconazole, a Potent CYP3A4 Inhibitor
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DOI: 10.1002/cpdd.1046
Abstract: The 5‐hydroxytryptamine type‐4 receptor agonist felcisetrag (TAK‐954) is being investigated for improving gastrointestinal motility in postoperative gastrointestinal dysfunction. Polypharmacy often occurs in this setting, and as in vitro data indicate, felcisetrag is primarily metabolized by… read more here.
Keywords: tak 954; cyp3a4; period; felcisetrag tak ... See more keywords
GLP‐1 receptor agonist use during hospitalisation: Better glycaemic control compared to premixed insulin
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DOI: 10.1002/dmrr.3574
Abstract: Glycaemic control associates with better outcomes for hospitalised patients. Whether GLP‐1 receptor agonists (GLP‐1 RA) are suitable and effective drugs for inpatients is unclear. read more here.
Keywords: glycaemic control; glp receptor; agonist use; receptor agonist ... See more keywords
Adiponectin receptor agonist AdipoRon attenuates calcification of osteoarthritis chondrocytes by promoting autophagy
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DOI: 10.1002/jcb.29605
Abstract: Cartilage calcification contributes to the development and progression of osteoarthritis (OA). It has been well‐investigated adiponectin regulates vascular calcification. The purpose of this study is to investigate the therapeutic value and the molecular mechanism of… read more here.
Keywords: receptor agonist; osteoarthritis; calcification; adiporon ... See more keywords
Combined treatment with a β3‐adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2017 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.23061
Abstract: This study determined if combined treatment with the muscarinic receptor (MR) antagonist solifenacin and the β3‐adrenergic receptor (AR) agonist mirabegron could inhibit detrusor overactivity induced by cold stress in spontaneously hypertensive rats (SHRs). read more here.
Keywords: receptor antagonist; receptor agonist; muscarinic receptor; receptor ... See more keywords
Improvement of urethral dysfunction by 5‐HT1A receptor agonist NLX‐112 in diabetic rats
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DOI: 10.1002/nau.24993
Abstract: To examine the effects of the selective 5‐HT1A receptor agonist, NLX‐112, on urethral function in streptozotocin‐induced diabetic rats. read more here.
Keywords: diabetic rats; agonist nlx; ht1a receptor; nlx 112 ... See more keywords
Effect of Clonidine Hydrochloride on Isolated Newborn Rat Heart.
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DOI: 10.1007/s10517-021-05347-5
Abstract: The concentration dependenies of the chronotropic response and changes in blood supply to the isolated heart of 7-day-old newborn rats induced by application of α2-adrenergic receptor agonist clonidine hydrochloride in concentrations of 10-9-10-6 M were… read more here.
Keywords: adrenergic receptor; concentration; heart; receptor agonist ... See more keywords
A promising drug candidate for the treatment of glaucoma based on a P2Y6-receptor agonist
Sign Up to like & getrecommendations! Published in 2018 at "Purinergic Signalling"
DOI: 10.1007/s11302-018-9614-7
Abstract: Extracellular nucleotides can regulate the production/drainage of the aqueous humor via activation of P2 receptors, thus affecting the intraocular pressure (IOP). We evaluated 5-OMe-UDP(α-B), 1A, a potent P2Y6-receptor agonist, for reducing IOP and treating glaucoma.… read more here.
Keywords: receptor; treatment glaucoma; p2y6 receptor; receptor agonist ... See more keywords