Aryl Hydrocarbon Receptor (AhR)–Independent Amiodarone (AMD) Toxicity in HepG2 Cell Line
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4844
Abstract: Amiodarone (AMD) is one of the most effective antiarrhythmic agents; however, its clinical use is limited by potential adverse effects, particularly hepatotoxicity, which occurs in 14%–82% of treated patients. Moreover, severe liver injury develops in… read more here.
Keywords: receptor; receptor ahr; hydrocarbon receptor; amiodarone amd ... See more keywords
Aryl hydrocarbon receptor (AHR) functions in NAD+ metabolism, myelopoiesis and obesity
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.02.021
Abstract: Graphical abstract Figure. No caption available. &NA; Diverse physiologic functions of AHR, a transcription factor discovered in studies of dioxin toxicity, are currently elucidated in many laboratories including chemical and microbial defense, immunity and myelopoiesis.… read more here.
Keywords: hydrocarbon receptor; aryl hydrocarbon; obesity; myelopoiesis ... See more keywords
Role of the aryl hydrocarbon receptor (AhR) signaling pathway in exceptional longevity in humans
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.361
Abstract: Centenarians are the best example of successfully aging in humans. Thus, the characterization of the biological processes and pathways in this population is an excellent strategy to understand the lifespan extension. The aryl hydrocarbon receptor… read more here.
Keywords: ahr signaling; longevity; hydrocarbon receptor; aryl hydrocarbon ... See more keywords
Aryl hydrocarbon receptor (AhR) a possible target for the treatment of skin disease.
Sign Up to like & getrecommendations! Published in 2018 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2018.05.001
Abstract: Aryl hydrocarbon receptor (AhR) is a transcription factor expressed in all skin cells type. It responds to exogenous and endogenous chemicals by inducing/repressing the expression of several genes with toxic or protective effects in a… read more here.
Keywords: treatment; hydrocarbon receptor; skin; aryl hydrocarbon ... See more keywords
The Aryl Hydrocarbon Receptor (AHR): Peacekeeper of the Skin
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DOI: 10.3390/ijms26041618
Abstract: In the last decade, the aryl hydrocarbon receptor (AHR) has emerged as a critical peacekeeper for the maintenance of healthy skin. The evolutionary conservation of AHR implied physiological functions for this receptor, beyond the detoxification… read more here.
Keywords: receptor ahr; hydrocarbon receptor; aryl hydrocarbon; skin ... See more keywords
Aryl Hydrocarbon Receptor (AHR) Suppresses Arsenic (As3+)-Induced Malignant Transformation by Antagonizing TOX Expression
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DOI: 10.7150/ijbs.107268
Abstract: Environmental arsenic (As³⁺) exposure poses a significant public health concern due to its carcinogenic potential. Our previous research suggests that As³⁺-induced carcinogenesis is mediated by inhibition of the aryl hydrocarbon receptor (AHR). However, the precise… read more here.
Keywords: induced malignant; receptor ahr; malignant transformation; hydrocarbon receptor ... See more keywords