The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes.
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DOI: 10.1182/blood-2017-04-780692
Abstract: The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin… read more here.
Keywords: receptor alk2; expression; type; immunophilin fkbp12 ... See more keywords