Codon adaptation by synonymous mutations impacts the functional properties of the estrogen receptor-alpha protein in breast cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13399
Abstract: Estrogen receptor-alpha (ERα) positivity is intimately associated with the development of hormone-dependent breast cancers. A major challenge in the treatment of these cancers is to understand and overcome the mechanisms of endocrine resistance. Recently, two… read more here.
Keywords: estrogen receptor; codon adaptation; receptor alpha; functional properties ... See more keywords
Investigation of selective retinoic acid receptor alpha antagonist ER-50891 and related analogs for male contraception.
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300031
Abstract: Retinoic acid receptor alpha (RARα) antagonist ER-50891 and 15 analogs were prepared and tested in vitro for potency and selectivity at RARα, RARβ, and RARγ using transactivation assays. Minor modifications to the parent molecule such… read more here.
Keywords: receptor alpha; antagonist 50891; retinoic acid; acid receptor ... See more keywords
Hypoxia differentially regulates estrogen receptor alpha in 2D and 3D culture formats.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.05.025
Abstract: Hypoxia is a common feature in solid tumors. Clinical samples show a positive correlation between the expression of the hypoxia-inducible factor HIF-1α and estrogen receptor alpha (ERα) and a negative correlation between HIF-1α and hormone… read more here.
Keywords: differentially regulates; receptor alpha; hypoxia; hypoxia differentially ... See more keywords
Nicotinic acetylcholine receptor alpha 7 stimulation dampens splenic myelopoiesis and inhibits atherogenesis in Apoe-/- mice.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.08.010
Abstract: BACKGROUND AND AIMS Monocyte levels predict cardiovascular outcomes and play a causal role in atherogenesis. Monocytes can be produced in the spleen and track to the atherosclerotic lesion in significant numbers. The cholinergic system has… read more here.
Keywords: splenic myelopoiesis; stimulation; receptor alpha; nicotinic acetylcholine ... See more keywords
Interleukin 7 receptor alpha Thr244Ile genetic polymorphism is associated with susceptibility and prognostic markers in breast cancer subgroups
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2017.09.019
Abstract: Abstract Interleukin‐7 (IL‐7) exerts crucial functions on lymphoid cells’ development and maintenance. In breast cancer (BC), IL‐7 promotes growth of tumor cells in culture through the activation of JAK1/3‐STAT5 and PI3K/AKT pathways, and expression of… read more here.
Keywords: susceptibility; receptor alpha; breast cancer; receptor ... See more keywords
Nicotinic acetylcholine receptor alpha 1(nAChRα1) subunit peptides as potential antiviral agents against rabies virus.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.05.179
Abstract: Rabies virus (RABV) is neurotropic and infects all warm-blooded animals. The binding of the virus with host cell receptor components is critical for infection. The present study reports the interaction of nicotinic acetylcholine receptor alpha… read more here.
Keywords: rabies virus; alpha nachr; receptor alpha; nicotinic acetylcholine ... See more keywords
Correlation between the expression of folate receptor alpha (FRα) and clinicopathological features in patients with lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Lung cancer"
DOI: 10.1016/j.lungcan.2020.05.002
Abstract: OBJECTIVES Folate receptor alpha (FRα) is expressed on the cell surface, mediates its intracellular transport via receptor-mediated endocytosis, and is involved in cell division. Whether FRα could be a potential therapeutic target in FRα-expressing cancers… read more here.
Keywords: receptor alpha; expression; folate receptor; clinicopathological features ... See more keywords
Epigenetic disruption of estrogen receptor alpha is induced by a glyphosate-based herbicide in the preimplantation uterus of rats
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.10.022
Abstract: Previously, we have shown that perinatal exposure to a glyphosate-based herbicide (GBH) induces implantation failures in rats. Estrogen receptor alpha (ERα) is critical for successful implantation. ERα transcription is under the control of five promoters… read more here.
Keywords: glyphosate based; receptor alpha; gbh; based herbicide ... See more keywords
Characterization of folate receptor alpha (FRα) expression in archival tumor and biopsy samples in a phase I study of mirvetuximab soravtansine, a FRα-targeting antibody-drug conjugate (ADC), in relapsed epithelial ovarian cancer patients
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic Oncology"
DOI: 10.1016/j.ygyno.2017.03.089
Abstract: Characterization of folate receptor alpha (FRα) expression in archival tumor and biopsy samples in a Phase I study of mirvetuximab soravtansine, a FRα-targeting antibody drug conjugate (ADC), in relapsed epithelial ovarian cancer patients Lainie P.… read more here.
Keywords: expression archival; receptor alpha; characterization folate; alpha expression ... See more keywords
Estrogen receptor alpha is required in GABAergic, but not glutamatergic, neurons to masculinize behavior
Sign Up to like & getrecommendations! Published in 2017 at "Hormones and Behavior"
DOI: 10.1016/j.yhbeh.2017.07.001
Abstract: ABSTRACT Masculinization of the altricial rodent brain is driven by estrogen signaling during a perinatal critical period. Genetic deletion of estrogen receptor alpha (Esr1/ER&agr;) results in altered hypothalamic‐pituitary‐gonadal (HPG) axis signaling and a dramatic reduction… read more here.
Keywords: sexual territorial; receptor alpha; estrogen; receptor ... See more keywords
Identification of a peptide for folate receptor alpha by phage display and its tumor targeting activity in ovary cancer xenograft
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-26683-z
Abstract: The expression level of folate receptor alpha (FRα) is located highly rate in ovarian cancer though it is remained absent in normal tissues. This highly tumor restricted expression profile makes FRα a promising target for… read more here.
Keywords: phage display; phage; receptor alpha; tumor targeting ... See more keywords