Impact of Muscarinic M3 Receptor Antagonism on the Risk of Type 2 Diabetes in Antidepressant-Treated Patients: A Case-Controlled Study
Sign Up to like & getrecommendations! Published in 2017 at "CNS Drugs"
DOI: 10.1007/s40263-017-0436-x
Abstract: BackgroundM3 muscarinic receptor antagonism has been associated with glucose intolerance and disturbance of insulin secretion.ObjectiveOur objective was to examine the risk of type 2 diabetes mellitus (T2DM) in patients using antidepressants with and without M3… read more here.
Keywords: t2dm; risk; muscarinic receptor; receptor antagonism ... See more keywords
Systemic calcitonin gene-related peptide receptor antagonism decreases survival in a large animal model of polymicrobial sepsis: blinded randomised controlled laboratory trial.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2021.11.042
Abstract: BACKGROUND Calcitonin gene-related peptide (CGRP) and procalcitonin, which are overexpressed in sepsis, exert distinct immunomodulatory effects mediated through the CGRP receptor. The CGRP receptor antagonist olcegepant improves survival in murine sepsis. This study evaluated whether… read more here.
Keywords: receptor antagonism; sepsis; model polymicrobial; polymicrobial sepsis ... See more keywords
Preadolescent dopamine receptor antagonism increases postadolescent reward-related operant behaviors that may depend on dopamine receptor hypersensitivity
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134917
Abstract: The dopaminergic system has a long history of being associated with reward-related activities but the developmental consequences of blocking dopamine receptor function on reward-based associative learning has been less studied. To this end, male, Long… read more here.
Keywords: reward related; receptor antagonism; dopamine receptor; receptor ... See more keywords
Muscarinic M1, but not M4, receptor antagonism impairs divided attention in male rats
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2021.173184
Abstract: Divided attention may be more important than ever to comprehend, given ubiquitous distractors in modern living. In humans, concern has been expressed about the negative impact of distraction in education, the home, and the workplace.… read more here.
Keywords: task; receptor antagonism; attention; muscarinic receptor ... See more keywords
Development of potential therapeutics for pain treatment by inducing Sigma 1 receptor antagonism – in silico approach
Sign Up to like & getrecommendations! Published in 2021 at "New Journal of Chemistry"
DOI: 10.1039/d1nj00883h
Abstract: The sigma 1 receptor antagonism is deemed a promising pain treatment approach. The research paper outlines conformational-independent QSAR modeling for a range of compounds which serve as sigma 1 receptor antagonists. The SMILES notation and… read more here.
Keywords: sigma receptor; pain treatment; receptor antagonism; receptor ... See more keywords
Has the utilization of serotonin receptor antagonism made an impact on schizophrenia treatment?
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2137403
Abstract: The introduction of atypical, i.e. second generation, antipsychotics (AAPs) since the discovery of clozapine, has been a big step in schizophrenia treatment. They are ‘atypical’ as their clinical profile differs from typical (first-generation) antipsychotics. All… read more here.
Keywords: serotonin; antagonism; treatment; receptor ... See more keywords
Interleukin-1 Receptor Antagonism as Adjunct Therapy for Heart Failure Patients with Left Ventricular Assist Devices.
Sign Up to like & getrecommendations! Published in 2021 at "ASAIO Journal"
DOI: 10.1097/mat.0000000000001347
Abstract: While left ventricular assist devices (LVAD) successfully unload the failing ventricle, most hearts do not regain sufficient function to allow for device explantation. Herein, we report a pilot series of LVAD patients treated with interleukin-1… read more here.
Keywords: interleukin receptor; left ventricular; receptor antagonism; heart ... See more keywords
Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14657
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease typically more common in males, implicating androgens in progression of both patients and mouse models. Androgen effects are mediated by androgen receptor which is highly expressed… read more here.
Keywords: receptor antagonism; amyotrophic lateral; receptor; androgen receptor ... See more keywords
Leukotriene receptor antagonism may not be effective in atopic dermatitis treatment after all
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.12648
Abstract: Literature evidence suggests leukotriene involvement in the pathogenesis of atopic dermatitis. This article aimed to discuss whether the off‐label use of montelukast, a leukotriene receptor antagonist, is justifiable for the treatment of atopic dermatitis. read more here.
Keywords: leukotriene receptor; receptor antagonism; treatment; atopic dermatitis ... See more keywords
Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0113
Abstract: Extracellular adenosine in the tumor microenvironment can impair antitumor immunity by suppressing CTL responses. Inhibition of adenosine signaling stabilizes CTL–target cell conjugation and increases sublethal hit frequency, and thereby restores CTL-mediated cytotoxicity against antigenic melanoma… read more here.
Keywords: cytotoxicity; adenosine a2a; antagonism restores; restores additive ... See more keywords
Androgen receptor (AR) antagonism triggers acute succinate‐mediated adaptive responses to reactivate AR signaling
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202013427
Abstract: Treatment‐induced adaptive pathways converge to support androgen receptor (AR) reactivation and emergence of castration‐resistant prostate cancer (PCa) after AR pathway inhibition (ARPI). We set out to explore poorly defined acute adaptive responses that orchestrate shifts… read more here.
Keywords: adaptive responses; androgen; receptor antagonism; succinate ... See more keywords