Use of Leukotriene-Receptor Antagonists During Pregnancy and Risk of Neuropsychiatric Events in Offspring
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.1934
Abstract: This cohort study examines the association of the use of leukotriene-receptor antagonists during pregnancy with the risk of neuropsychiatric events in offspring. read more here.
Keywords: pregnancy risk; antagonists pregnancy; risk neuropsychiatric; receptor antagonists ... See more keywords
Anti‐migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25831
Abstract: Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging treatments for migraine. CGRP‐mediated vasodilation is, however, a critical rescue mechanism in ischemia. We, therefore, investigated whether gepants, small molecule CGRP receptor antagonists, worsen cerebral ischemia. read more here.
Keywords: antagonists worsen; related peptide; gene related; calcitonin gene ... See more keywords
5‐HT7 Receptor Antagonists with an Unprecedented Selectivity Profile
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800026
Abstract: Selective leads: In this study, we generated a new series of serotonin 5-HT7 receptor antagonists. Their synthesis, structure-activity relationships, and selectivity profiles are reported. This series includes 5-HT7 antagonists with unprecedented high selectivity for the… read more here.
Keywords: antagonists unprecedented; ht7 receptor; unprecedented selectivity; receptor antagonists ... See more keywords
GluN2A‐Selective NMDA Receptor Antagonists: Mimicking the U‐Shaped Bioactive Conformation of TCN‐201 by a [2.2]Paracyclophane System
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200484
Abstract: Under physiological conditions, N‐Methyl‐D‐Aspartate (NMDA) receptors play a crucial role for synaptic plasticity, long‐term potentiation and long‐term depression. However, overactivation of NMDA receptors can result in excitotoxicity, which is associated with various neurological and neurodegenerative… read more here.
Keywords: nmda receptor; tcn 201; receptor antagonists; selective nmda ... See more keywords
Stopping mineralocorticoid receptor antagonists after hyperkalemia: trial emulation in data from routine care.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of heart failure"
DOI: 10.1002/ejhf.2287
Abstract: AIMS Whether to continue or stop mineralocorticoid receptor antagonists (MRA) after an episode of hyperkalemia is a challenge in clinical practice. While stopping MRA may prevent recurrent hyperkalemias, it deprives patients of their cardioprotection. We… read more here.
Keywords: trial emulation; heart failure; mineralocorticoid receptor; hyperkalemia ... See more keywords
Temporal trends in initiation of mineralocorticoid receptor antagonists and risk of subsequent withdrawal in patients with heart failure: A nationwide study in Denmark from 2003-2017.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of heart failure"
DOI: 10.1002/ejhf.2418
Abstract: AIMS Despite landmark heart failure (HF) with reduced ejection fraction (HFrEF) trials showing effect of Mineralocorticoid Receptor Antagonists (MRA) on the risk of death and HF hospitalization, it has been suggested that MRAs are underutilized… read more here.
Keywords: mineralocorticoid receptor; receptor antagonists; heart failure; withdrawal ... See more keywords
A promise unfulfilled: the use of mineralocorticoid receptor antagonists in patients with heart failure and a reduced left ventricular ejection fraction
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2441
Abstract: This article refers to ‘Temporal trends in initiation of mineralocorticoid receptor antagonists and risk of subsequent withdrawal in patients with heart failure: a nationwide study in Denmark from 2003–20 1 7’ by D. Zahir et… read more here.
Keywords: mineralocorticoid receptor; heart; receptor antagonists; patients heart ... See more keywords
Effects of steroidal mineralocorticoid receptor antagonists on acute and chronic estimated glomerular filtration rate slopes in patients with chronic heart failure
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2635
Abstract: Steroidal mineralocorticoid receptor antagonists (MRAs) form a cornerstone of the management of heart failure (HF), but little is known about the long‐term effects of MRA therapy on kidney function. We evaluated acute and chronic estimated… read more here.
Keywords: heart failure; heart; mineralocorticoid receptor; receptor antagonists ... See more keywords
Topiramate and other kainate receptor antagonists for depression: A systematic review of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12284
Abstract: Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the… read more here.
Keywords: topiramate kainate; antagonists depression; depression systematic; kainate receptor ... See more keywords
NMDA Receptor Antagonists
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1007/978-3-319-99124-5_62
Abstract: NMDA receptor antagonists have a number of indications in chronic and acute pain. While ketamine represents the most frequently utilized analgesic from this group, other agents possess similar properties. The use of ketamine has been… read more here.
Keywords: receptor antagonists; nmda receptor;
Comparative molecular field analysis and molecular dynamics studies of the dopamine D2 receptor antagonists without a protonatable nitrogen atom
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2137-5
Abstract: AbstractThe dopaminergic hypothesis of schizophrenia is the main concept explaining the direct reasons of schizophrenia and the effectiveness of current antipsychotics. All antipsychotics present on the market are potent dopamine D2 receptor antagonists or partial… read more here.
Keywords: receptor; nitrogen atom; receptor antagonists; dopamine receptor ... See more keywords