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   Articles with "receptor associated" as a keyword



TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.03.186

Abstract: Oncostatin M (OSM) is involved in pathogenesis of several human inflammatory diseases including lung inflammation and fibrosis. Although accumulating evidence indicates that OSM mediates lung inflammation, the precise mechanism for OSM on lung inflammation still… read more here.

Keywords: tnf receptor; inflammation; lung inflammation; receptor associated ... See more keywords

Molecular and functional characterization of pigeon (Columba livia) tumor necrosis factor receptor‐associated factor 3

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recommendations! Published in 2017 at "Developmental and Comparative Immunology"

DOI: 10.1016/j.dci.2016.12.005

Abstract: ABSTRACT Tumor necrosis factor receptor‐associated factor 3 (TRAF3) plays a key antiviral role by promoting type I interferon production. We cloned the pigeon TRAF3 gene (PiTRAF3) according to its predicted mRNA sequence to investigate its… read more here.

Keywords: pigeon; tumor necrosis; factor receptor; factor ... See more keywords

Identification and characterization of a TNF receptor-associated factor in Dugesia japonica.

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recommendations! Published in 2019 at "Gene"

DOI: 10.1016/j.gene.2018.09.038

Abstract: The tumor necrosis factor (TNF) superfamily consists of a wide variety of inflammatory cytokine, including cell-bound and secreted proteins. These TNFs function through binding and activation of the TNF receptors for modulating TNF-associated intracellular signals.… read more here.

Keywords: tnf; dugesia japonica; factor; tnf receptor ... See more keywords
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Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins

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recommendations! Published in 2017 at "Neuron"

DOI: 10.1016/j.neuron.2017.10.001

Abstract: Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimension for… read more here.

Keywords: associated proteins; handle neuropharmacology; getting handle; neuropharmacology targeting ... See more keywords

H4 Receptor Inhibits Lipopolysaccharide-induced NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor-Associated Factor 6

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recommendations! Published in 2019 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2018.11.050

Abstract: Microglia, the resident immune cells of the central nervous system (CNS), are activated at the beginning of the inflammatory response and induce detrimental neuroinflammation by producing excessive pro-inflammatory cytokines. Nuclear factor kappa B (NF-κB) signaling… read more here.

Keywords: tumor necrosis; receptor; factor receptor; factor ... See more keywords

Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases.

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recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c00181

Abstract: Interleukin-1 receptor-associated kinase 4 (IRAK4) is a promising therapeutic target in inflammation-related diseases. However, the inhibition of IRAK4 kinase activity may lead to moderate anti-inflammatory efficacy owing to the dual role of IRAK4 as an… read more here.

Keywords: interleukin receptor; associated kinase; receptor associated; irak4 ... See more keywords
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Pneumococcal Serotype-specific Opsonophagocytic Activity in Interleukin-1 Receptor-associated Kinase 4-deficient Patients.

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recommendations! Published in 2021 at "Pediatric Infectious Disease Journal"

DOI: 10.1097/inf.0000000000003060

Abstract: BACKGROUND The antibody response after pneumococcal vaccines and their effectiveness against invasive pneumococcal disease (IPD) in patients with interleukin-1 receptor-associated kinase 4 (IRAK4) deficiency have not been fully evaluated. Here, we evaluated pneumococcal serotype-specific opsonophagocytic… read more here.

Keywords: interleukin receptor; pneumococcal serotype; associated kinase; deficient patients ... See more keywords

Clinical analysis of Chinese anti‐low‐density‐lipoprotein‐receptor‐associated protein 4 antibodies in patients with myasthenia gravis

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recommendations! Published in 2019 at "European Journal of Neurology"

DOI: 10.1111/ene.13979

Abstract: Low‐density‐lipoprotein‐receptor‐associated protein 4 (LRP4) autoantibodies have recently been detected in myasthenia gravis (MG), but little is known about the clinical characteristics associated with this serological type. In this study, the clinical features of Chinese patients… read more here.

Keywords: associated protein; density lipoprotein; low density; myasthenia gravis ... See more keywords

Toxoplasma GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors

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recommendations! Published in 2019 at "mBio"

DOI: 10.1128/mbio.00808-19

Abstract: The parasite Toxoplasma can cause birth defects and severe disease in immunosuppressed patients. Strain differences in pathogenicity exist, and these differences are due to polymorphic effector proteins that Toxoplasma secretes into the host cell to… read more here.

Keywords: activation; gra15; receptor associated; factor ... See more keywords

A novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature.

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recommendations! Published in 2022 at "Rheumatology"

DOI: 10.1136/annrheumdis-2022-eular.1098

Abstract: OBJECTIVE We describe a family with a novel mutation in the TNF Receptor Superfamily Member 1A gene (TNFRSF1A) causing tumour necrosis factor receptor-associated periodic syndrome (TRAPS) with renal AA-amyloidosis. METHODS Case series of affected family… read more here.

Keywords: tnf receptor; associated periodic; treatment; mutation ... See more keywords

The Role of Interleukin-1 Receptor-Associated Kinase M in Pulmonary Diseases: Mechanisms and Therapeutic Implications

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recommendations! Published in 2025 at "Journal of Innate Immunity"

DOI: 10.1159/000548123

Abstract: Abstract Background: Respiratory system diseases, including infections, inflammation, fibrosis, cancer, and others, impose a substantial burden on human health worldwide. The respiratory tract is constantly exposed to external stimuli due to its connection with the… read more here.

Keywords: interleukin receptor; receptor; pulmonary diseases; role ... See more keywords