Impact of prior androgen receptor-axis-targeted agents on the clinical activity of subsequent docetaxel in patients with metastatic castration-resistant prostate cancer: comparative assessment between abiraterone acetate and enzalutamide
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DOI: 10.1007/s12032-017-1060-9
Abstract: The objective of this study was to investigate the impact of prior treatment with androgen receptor-axis-targeted (ARAT) agents, abiraterone acetate (AA) and enzalutamide (Enz), on the activity of subsequently introduced docetaxel in patients with metastatic… read more here.
Keywords: psa; impact; receptor axis; androgen receptor ... See more keywords
The role of the interleukin (IL)-6/IL-6 receptor axis in cancer.
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DOI: 10.1042/bst20180136
Abstract: Interleukin-6 (IL-6) is a pleiotropic cytokine that activates a classic signalling pathway upon binding to its membrane-bound receptor (IL-6R). Alternatively, IL-6 may 'trans-signal' in a manner that is facilitated by its binding to a soluble… read more here.
Keywords: role interleukin; receptor axis; cancer; receptor ... See more keywords
Propensity score‐matched comparison of docetaxel and androgen receptor axis‐targeted agents in patients with castration‐resistant intraductal carcinoma of the prostate
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DOI: 10.1111/bju.14970
Abstract: To evaluate the efficacy of docetaxel and androgen receptor axis‐targeted (ARAT) agents in patients with castration‐resistant prostate cancer (CRPC) with intraductal carcinoma of the prostate (IDC‐P) using a propensity score‐matched analysis. read more here.
Keywords: prostate; docetaxel androgen; receptor axis; axis targeted ... See more keywords
Efficacy of docetaxel addition to next‐generation androgen receptor‐axis‐targeted therapies and androgen deprivation therapy in metastatic hormone‐sensitive prostate cancer: A tumor volume‐specific analysis
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DOI: 10.1111/iju.15657
Abstract: The effectiveness of docetaxel in addition to next‐generation androgen receptor‐axis‐targeted therapies and androgen deprivation therapy (ADT) for metastatic hormone‐sensitive prostate cancer (mHSPC) remains unclear. We evaluated the efficacy of this combination through tumor volume‐specific analysis. read more here.
Keywords: receptor axis; next generation; generation androgen; docetaxel addition ... See more keywords
Connecting Gene Variation to Treatment Outcomes in Metastatic Castration-Resistant Prostate Adenocarcinoma: Insights into Second-Generation Androgen Receptor Axis-Targeted Therapies
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DOI: 10.3390/ijms25189874
Abstract: Prostate cancer (PC) is one of the most commonly diagnosed tumours among men. Second-generation androgen receptor axis-targeted (ARAT) agents, namely abiraterone acetate (AbA) and enzalutamide (ENZ), are currently used in the management of metastatic castration-resistant… read more here.
Keywords: treatment; receptor axis; second generation; generation androgen ... See more keywords