Chimeric antigen receptor–based therapies beyond cancer
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250184
Abstract: Adoptive cell transfer (ACT) therapies have gained renewed interest in the field of immunotherapy following the advent of chimeric antigen receptor (CAR) technology. This immunological breakthrough requires immune cell engineering with an artificial surface protein… read more here.
Keywords: antigen receptor; chimeric antigen; car; receptor based ... See more keywords
Receptor-based pharmacophore modeling, virtual screening, and molecular docking studies for the discovery of novel GSK-3β inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-019-4032-5
Abstract: AbstractConsidering the emerging importance of glycogen synthase kinase 3 beta (GSK-3β) inhibitors in treatment of Alzheimer’s disease, multi-protein structure receptor-based pharmacophore modeling was adopted to generate a 3D pharmacophore model for (GSK-3β) inhibitors. The generated… read more here.
Keywords: based pharmacophore; receptor based; molecular docking; pharmacophore modeling ... See more keywords
A schiff-base receptor based naphthalimide derivative: Highly selective and colorimetric fluorescent turn-on sensor for Al3+
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Luminescence"
DOI: 10.1016/j.jlumin.2016.12.056
Abstract: Abstract A new schiff-base receptor L based on naphthalimide had been investigated as a selective and sensitive chemosensor for Al 3+ in CH 3 OH. Upon addition of Al 3+ , L showed a 39-fold… read more here.
Keywords: receptor based; base receptor; based naphthalimide; schiff base ... See more keywords
Receptor-based screening assays for the detection of antibiotics residues - A review.
Sign Up to like & getrecommendations! Published in 2017 at "Talanta"
DOI: 10.1016/j.talanta.2017.01.057
Abstract: Consumer and regulatory agencies have a high concern to antibiotic residues in food producing animals, so appropriate screening assays of fast, sensitive, low cost, and easy sample preparation for the identification of these residues are… read more here.
Keywords: detection; screening assays; receptor based; receptor ... See more keywords
Receptor-Based Peptides for Inhibition of Leukotoxin Activity.
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.7b00230
Abstract: The Gram-negative bacterium Aggregatibacter actinomycetemcomitans, commonly associated with localized aggressive periodontitis (LAP), secretes an RTX (repeats-in-toxin) protein leukotoxin (LtxA) that targets human white blood cells, an interaction that is driven by its recognition of the… read more here.
Keywords: receptor based; inhibit ltxa; peptides inhibition; activity ... See more keywords
Targeting the receptor-based interactome of the dopamine D1 receptor: looking for heteromer-selective drugs
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2019.1664469
Abstract: ABSTRACT Introduction: G protein-coupled receptors (GPCRs) are a superfamily of membrane proteins highly expressed in the brain that are involved in almost all functions of the CNS. During the last twenty years, a large number… read more here.
Keywords: based interactome; drugs targeting; receptor based; dopamine receptor ... See more keywords
The Antibody Response to Plasmodium falciparum: Cues for Vaccine Design and the Discovery of Receptor-Based Antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-042617-053301
Abstract: Plasmodium falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the… read more here.
Keywords: receptor based; vaccine design; plasmodium falciparum; antibody response ... See more keywords
Synthetic Receptor-Based Targeting Strategies to Improve Tumor Drug Delivery.
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-021-01919-w
Abstract: Heterogeneity in tumor expression as well as expression in normal tissues of various targets limit the usefulness of current ligand-based active targeting approaches. Incorporation of synthetic receptors, which can be recognized by delivery systems engineered… read more here.
Keywords: receptor based; delivery; improve tumor; synthetic receptor ... See more keywords
The Emergence of Insect Odorant Receptor-Based Biosensors
Sign Up to like & getrecommendations! Published in 2020 at "Biosensors"
DOI: 10.3390/bios10030026
Abstract: The olfactory receptor neurons of insects and vertebrates are gated by odorant receptor (OR) proteins of which several members have been shown to exhibit remarkable sensitivity and selectivity towards volatile organic compounds of significant importance… read more here.
Keywords: insect odorant; emergence insect; receptor based; biosensors emergence ... See more keywords
PSMA Receptor-Based PET-CT: The Basics and Current Status in Clinical and Research Applications
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13010158
Abstract: Prostate-specific membrane antigen (PSMA) is a 100 kD, 750 amino acid (AA) long type II transmembrane glycoprotein that has a short N-terminal intracellular domain with 19 AA, 24 AA transmembrane proteins and a large C-terminal… read more here.
Keywords: psma receptor; receptor based; psma; based pet ... See more keywords