Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates
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DOI: 10.1002/advs.202414931
Abstract: Clinical trials of receptor‐biased interleukin‐2 (IL‐2) variants in cancer therapy show limited efficacy. To investigate, we re‐evaluated divergent receptor‐biased IL‐2 PEGylates (generated via site‐specific PEGylation at residues D20 (not‐β) and Y45 (not‐α)), alone or in… read more here.
Keywords: divergent receptor; receptor biased; cd8 cells; cd8 ... See more keywords
[18F]FDG PET metabolic patterns of the rapid-acting antidepressant effects of NLX-101, a 5-HT1A receptor biased agonist
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DOI: 10.1038/s41398-025-03572-4
Abstract: Rapid-acting antidepressants (RAADs) such as ketamine are currently under development. The aim of this study is to characterize the neural circuits affected by ketamine and NLX-101, a selective 5-HT1A receptor biased agonist which has shown… read more here.
Keywords: receptor biased; brain; biased agonist; 18f fdg ... See more keywords
Structural Insights into CB1 Receptor Biased Signaling
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DOI: 10.3390/ijms20081837
Abstract: The endocannabinoid system has emerged as a promising target for the treatment of numerous diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Thus far, two cannabinoid receptors, CB1 and CB2, have been discovered, which are… read more here.
Keywords: biased signaling; cb1 receptor; structural insights; receptor biased ... See more keywords