Clinical practice: chimeric antigen receptor (CAR) T cells: a major breakthrough in the battle against cancer
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-020-00628-1
Abstract: Chimeric antigen receptor (CAR) T cell therapy has come of age, offering a potentially curative option for patients who are refractory to standard anti-cancer treatments. The success of CAR T cell therapy in the setting… read more here.
Keywords: cell; receptor car; car cells; antigen receptor ... See more keywords
Current strategies to improve the safety of chimeric antigen receptor (CAR) modified T cells.
Sign Up to like & getrecommendations! Published in 2017 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.08.018
Abstract: Adoptive immunotherapy adopting chimeric antigen receptor (CAR) modified T cells has arisen attention as a hard-hitting therapy for numerous cancers. CARs are genetically engineered receptors that could stimulate tumor cytotoxicity once binding to the specific… read more here.
Keywords: chimeric antigen; modified cells; receptor car; antigen receptor ... See more keywords
Current Molecular Advancements in Chimeric Antigen Receptor (CAR-T) Cells for the Treatment of Leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of adolescent and young adult oncology"
DOI: 10.1089/jayao.2021.0102
Abstract: Chimeric antigen receptor T (CAR-T) is a relatively new treatment for pediatric leukemia and has been the focused of recent advancements. CAR is manufactured to express T cells through various ways such as using retroviruses,… read more here.
Keywords: receptor car; antigen receptor; antigen; chimeric antigen ... See more keywords
Constitutive androstane receptor (CAR) mediates pyrene‐induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15934
Abstract: The constitutive androstane receptor (CAR), a known xenobiotic sensor, plays an important role in drug metabolism by regulating numerous genes. The polycyclic aromatic hydrocarbon pyrene, an environmental pollutant, is a CAR activator and induces mouse… read more here.
Keywords: car; receptor car; constitutive androstane; androstane receptor ... See more keywords
Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance
Sign Up to like & getrecommendations! Published in 2018 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-018-0460-5
Abstract: Chimeric Antigen Receptor (CAR) T cell therapies – adoptive T cell therapies that have been genetically engineered for a new antigen-specificity - have displayed significant success in treating patients with hematologic malignancies, leading to three… read more here.
Keywords: hematologic malignancies; receptor car; antigen; antigen receptor ... See more keywords
Interleukin-12 armored chimeric antigen receptor (CAR) T cells for heterogeneous antigen-expressing ovarian cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.5_suppl.12
Abstract: 12Background: Immune escape via downregulation of tumor associated antigens (TAAs) is an important mechanism of resistance to Chimeric Antigen Receptor (CAR) T cell therapy. Particularly in solid tumor malignancies where antigen expression could be heterogeneous,… read more here.
Keywords: antigen; receptor car; car cells; antigen receptor ... See more keywords
Chimeric antigen receptor (CAR) T-cell therapy as a treatment option for patients with B-cell lymphomas: perspectives on the therapeutic potential of Axicabtagene ciloleucel
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s163225
Abstract: Abstract Axicabtagene lisoleucel (Axi-cel) is the second approved gene-alterating cancer treatment and the first in aggressive lymphoma using the “chimeric antigen receptor” (CAR) technology. T-cells from patients were transfected with CARs and reinfused after a… read more here.
Keywords: receptor car; axicabtagene; treatment; antigen receptor ... See more keywords
Special Chimeric Antigen Receptor (CAR) Modifications of T Cells: A Review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.832765
Abstract: Chimeric antigen receptor (CAR) -T cell therapy has become one of the hot topics in tumor immunity research in recent years. Although CAR-T cell therapy is highly effective in treating hematological malignancies, there are numerous… read more here.
Keywords: car; receptor car; chimeric antigen; antigen receptor ... See more keywords
Combining selective inhibitors of nuclear export (SINEs) with chimeric antigen receptor (CAR) T cells for CD19-positive malignancies
Sign Up to like & getrecommendations! Published in 2021 at "Oncology Reports"
DOI: 10.3892/or.2021.8121
Abstract: Chimeric antigen receptor (CAR) T cells directed against CD19 (CD19.CAR T cells) have yielded impressive clinical responses in the treatment of patients with lymphoid malignancies. However, resistance and/or relapse can limit treatment outcome. Risk of… read more here.
Keywords: receptor car; selective inhibitors; car cells; antigen receptor ... See more keywords