Chemokine receptor CCR1: new target for asthma therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2022.02.009
Abstract: A recent study shows that chemokine receptor 1 (CCR1) plays a role in eosinophilic inflammation and that its ligand CCL15 is increased in asthmatic eosinophils (Du et al.). A companion study reports that N-truncated forms… read more here.
Keywords: ccr1 new; therapy; new target; receptor ccr1 ... See more keywords
Targeting Chemokine Receptor CCR1 as a Potential Therapeutic Approach for Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.846310
Abstract: Multiple myeloma is an incurable plasma B-cell malignancy with 5-year survival rates approximately 10-30% lower than other hematologic cancers. Treatment options include combination chemotherapy followed by autologous stem cell transplantation. However, not all patients are… read more here.
Keywords: targeting chemokine; chemokine receptor; myeloma; multiple myeloma ... See more keywords
Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20102417
Abstract: Leukocyte migration, a hallmark of the inflammatory response, is stimulated by the interactions between chemokines, which are expressed in injured or infected tissues, and chemokine receptors, which are G protein-coupled receptors (GPCRs) expressed in the… read more here.
Keywords: receptor; biased agonism; receptor ccr1; chemokine receptor ... See more keywords