DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2018.1509173
Abstract: ABSTRACT Chimeric antigen receptor (CAR) T cell immunotherapies have shown remarkable efficacy in treating multiple types of hematological malignancies but are not sufficiently effective at treating solid tumors. NKG2D is a strong activating receptor for… read more here.
Keywords: efficacy; receptor cells; receptor; antigen receptor ... See more keywords
Multifocal Necrotizing Leukoencephalopathy With Preferential Microglia Toxicity in a Patient Treated With Chimeric Antigen Receptor T-Cells and Review of the Literature.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlaa099
Abstract: Neurotoxic side effects of traditional systemic chemotherapy are abundantly described. The introduction of newly developed biologic therapeutics and cellular immune effector therapies has expanded the spectrum of neurotoxicity. Multifocal necrotizing leukoencephalopathy (MNL) is a pathologic… read more here.
Keywords: patient treated; necrotizing leukoencephalopathy; multifocal necrotizing; receptor cells ... See more keywords
PI3K signalling in leptin receptor cells: Role in growth and reproduction
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12685
Abstract: Nutrition and growth are important signals for pubertal development, although how they are perceived and integrated in brain circuits has not been well defined. Growth hormones and metabolic cues both recruit phosphatidylinositol 3‐kinase (PI3K) signalling… read more here.
Keywords: role; pi3k signalling; growth; receptor cells ... See more keywords
Age‐related electrophysiological changes in mouse taste receptor cells
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Physiology"
DOI: 10.1113/ep089104
Abstract: What is the central question of this study? Loss of taste or inability to distinguish between different tastes progresses with age. The purpose was to evaluate the age‐dependent changes in taste by studying the electrophysiological… read more here.
Keywords: receptor cells; age related; taste receptor; taste ... See more keywords
Efficacy of CD19-targeted chimeric antigen receptor T cells in the treatment of relapsed extramedullary B-cell acute lymphoblastic leukemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e14549
Abstract: e14549Background: Chimeric antigen receptor T cells directed at CD19 (CART19) have shown promising results in the treatment of refractory/relapsed acute lymphoblastic leukemia and chronic lymphocyt... read more here.
Keywords: cell; lymphoblastic leukemia; receptor cells; acute lymphoblastic ... See more keywords
Chimeric antigen receptor-t cells (CAR-T) horizon scanning: Emerging targets in oncology and hematology.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e15031
Abstract: e15031Background: The launch of CAR-T cells raises major issues in terms of therapeutic strategies, safety, organization of care, financial sustainability. Regarding these challenges and the strong... read more here.
Keywords: hematology; oncology; receptor cells; antigen receptor ... See more keywords
A possible role for taste receptor cells in surveying the oral microbiome
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3001953
Abstract: Taste receptor cells are sensory specialists that detect chemicals in food and drink. An exciting new report in PLOS Biology suggests that some taste cells could also be involved in immune surveillance like counterparts in… read more here.
Keywords: taste; possible role; receptor cells; biology ... See more keywords
Immunotherapy of Neuroendocrine Neoplasms: Any Role for the Chimeric Antigen Receptor T Cells?
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14163991
Abstract: Simple Summary Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumors arising in different organs whose clinical course is variable according to histological differentiation and metastatic spread. Therapeutic options have recently expanded, but there is… read more here.
Keywords: antigen receptor; role; chimeric antigen; car ... See more keywords