The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release
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DOI: 10.3389/fimmu.2021.650808
Abstract: The myeloid inhibitory C-type lectin receptor CLEC12A limits neutrophil activation, pro-inflammatory pathways and disease in mouse models of inflammatory arthritis by a molecular mechanism that remains poorly understood. We addressed how CLEC12A-mediated inhibitory signaling counteracts… read more here.
Keywords: clec12a regulates; akt signaling; neutrophil activation; pi3k akt ... See more keywords