Cancer Cell-Selective Membrane Receptor Clustering Driven by VEGF Secretion for In Vivo Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10428
Abstract: Clustering of cell membrane receptors regulates cell behaviors. Although receptor clustering plans have achieved wide applications in cancer therapy, it still remains challenging to manipulate receptor clustering selectively for cancer cells with little influence on… read more here.
Keywords: cell; receptor clustering; therapy; membrane ... See more keywords
TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02309-5
Abstract: Monoclonal antibodies (mAb) and natural ligands targeting costimulatory tumor necrosis factor receptors (TNFR) exhibit a wide range of agonistic activities and antitumor responses. The mechanisms underlying these differential agonistic activities remain poorly understood. Here, we… read more here.
Keywords: receptor clusters; receptor clustering; differential agonistic; agonistic activity ... See more keywords
Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering
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DOI: 10.1038/s42003-022-03182-6
Abstract: Agonistic CD27 monoclonal antibodies (mAb) have demonstrated impressive anti-tumour efficacy in multiple preclinical models but modest clinical responses. This might reflect current reagents delivering suboptimal CD27 agonism. Here, using a novel panel of CD27 mAb… read more here.
Keywords: receptor clustering; engineering; agonistic cd27; cd27 ... See more keywords
Effect of receptor clustering on chemotactic performance of E. coli: Sensing versus adaptation.
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DOI: 10.1103/physreve.103.l030401
Abstract: We show how the competition between sensing and adaptation can result in a performance peak in Escherichia coli chemotaxis using extensive numerical simulations in a detailed theoretical model. Receptor clustering amplifies the input signal coming… read more here.
Keywords: adaptation; coli; effect receptor; performance ... See more keywords