Steroid receptor/coactivator binding inhibitors: An update
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110471
Abstract: The purpose of this review is to highlight recent developments in small molecules and peptides that block the binding of coactivators to steroid receptors. These coactivator binding inhibitors bind at the coregulator binding groove, also… read more here.
Keywords: receptor coactivator; binding inhibitors; steroid receptors; coactivator binding ... See more keywords
Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31372-y
Abstract: Steroid receptor coactivator-2 (SRC-2) is a transcriptional coregulator that modulates the activity of many transcription factors. Levels of SRC-2 are elevated in endometrial biopsies from polycystic ovary syndrome patients, a population predisposed to endometrial cancer… read more here.
Keywords: ppp; endometrial cancer; cancer; rpia ... See more keywords
Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator‐activated receptor γ coactivator‐1α‐deficient mice
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Physiology"
DOI: 10.1113/ep086629
Abstract: What is the central question of this study? Does a reduction in hepatic peroxisome proliferator‐activated receptor γ coactivator‐1α (PGC‐1α), which has been observed in an insulin‐resistant obese state, impair the ability of fibroblast growth factor… read more here.
Keywords: peroxisome proliferator; proliferator activated; fibroblast growth; hepatic peroxisome ... See more keywords
Increasing the level of peroxisome proliferator-activated receptor γ coactivator-1α in podocytes results in collapsing glomerulopathy.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.92930
Abstract: Inherited and acquired mitochondrial defects have been associated with podocyte dysfunction and chronic kidney disease (CKD). Peroxisome proliferator-activated receptor γ coactivator-1α (PGC1α) is one of the main transcriptional regulators of mitochondrial biogenesis and function. We… read more here.
Keywords: peroxisome proliferator; proliferator activated; pgc1; activated receptor ... See more keywords
Regulation of Hepatic Gluconeogenesis by Nuclear Receptor Coactivator 6
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.2222
Abstract: Nuclear receptor coactivator 6 (NCOA6) is a transcriptional coactivator of nuclear receptors and other transcription factors. A general Ncoa6 knockout mouse was previously shown to be embryonic lethal, but we here generated liver-specific Ncoa6 knockout… read more here.
Keywords: nuclear receptor; coactivator; lko mice; receptor coactivator ... See more keywords
Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrine-related cancer"
DOI: 10.1530/erc-19-0482
Abstract: Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy without effective therapeutic options to improve survival. Steroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator whose amplification and/or overexpression has been identified in many cancers. In this… read more here.
Keywords: cancer; steroid receptor; receptor coactivator; coactivator ... See more keywords
A steroid receptor coactivator small molecule “stimulator” attenuates post-stroke ischemic brain injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1055295
Abstract: Introduction: Pathologic remodeling of the brain following ischemic stroke results in neuronal loss, increased inflammation, oxidative stress, astrogliosis, and a progressive decrease in brain function. We recently demonstrated that stimulation of steroid receptor coactivator 3… read more here.
Keywords: steroid receptor; injury; brain; receptor coactivator ... See more keywords