Structure of the Insulin Receptor in Complex with Insulin using Single Particle CryoEM Analysis
Sign Up to like & getrecommendations! Published in 2017 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927617006596
Abstract: Insulin Receptor (IR) mediated signaling is crucial in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels [1, 2]. Aberrations in Insulin signaling have been associated with a variety of… read more here.
Keywords: insulin; complex insulin; receptor complex; insulin receptor ... See more keywords
Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00048
Abstract: An unbiased phenotypic neuronal assay was developed to measure the synaptotoxic effects of soluble Aβ oligomers. A collection of CNS druglike small molecules prepared by conditioned extraction was screened. Compounds that prevented and reversed synaptotoxic… read more here.
Keywords: drug ct1812; investigational drug; alzheimer disease; receptor complex ... See more keywords
Engineering plants to secrete affinity-tagged pathogen elicitors for deciphering immune receptor complex or inducing enhanced immunity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.12859
Abstract: Plant cells mount plenty of pattern-recognition receptors (PRRs) to detect the microbe-associated molecular patterns (MAMPs) from potential microbial pathogens. MAMPs are overrepresented by proteinaneous patterns, such as the flg22 peptide from bacterial flagellin. Identification of… read more here.
Keywords: receptor complex; engineering plants; affinity tagged; receptor ... See more keywords
Nanobody-driven signaling reveals the core receptor complex in root nodule symbiosis
Sign Up to like & getrecommendations! Published in 2023 at "Science"
DOI: 10.1126/science.ade9204
Abstract: Understanding the composition and activation of multicomponent receptor complexes is a challenge in biology. To address this, we developed a synthetic approach based on nanobodies to drive assembly and activation of cell surface receptors and… read more here.
Keywords: root; receptor complex; root nodule; receptor ... See more keywords
A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "eNeuro"
DOI: 10.1523/eneuro.0257-17.2017
Abstract: Abstract Neurotrophins play critical roles in the survival, maintenance and death of neurons. In particular, proneurotrophins have been shown to mediate cell death following brain injury induced by status epilepticus (SE) in rats. Previous studies… read more here.
Keywords: death; p75ntr; receptor complex; sortilin receptor ... See more keywords
The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.815356
Abstract: The incidence of cardiovascular diseases is increasing worldwide with the growing aging of the population. Biological aging has major influence on the vascular tree and is associated with critical changes in the morphology and function… read more here.
Keywords: emerging therapeutic; receptor complex; elastin receptor; complex emerging ... See more keywords
The Structure, Evolution, and Gene Expression Within the Caprine Leukocyte Receptor Complex
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02302
Abstract: The leukocyte receptor complex (LRC) encodes a large number of immunoglobulin (Ig)-like receptors involved in the immune response, particularly in modulating natural killer (NK) cell function. The killer cell Ig-like receptors (KIR), the leukocyte Ig-like… read more here.
Keywords: leukocyte receptor; evolution; receptor complex; like receptors ... See more keywords
Comparative genomics of the Leukocyte Receptor Complex in carnivores
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1197687
Abstract: Background The mammalian Leukocyte Receptor Complex (LRC) chromosomal region may contain gene families for the killer cell immunoglobulin-like receptor (KIR) and/or leukocyte immunoglobulin-like receptor (LILR) collections as well as various framing genes. This complex region… read more here.
Keywords: receptor complex; comparative genomics; genomics leukocyte; leukocyte receptor ... See more keywords
The α2δ-1-NMDA receptor complex and its potential as a therapeutic target for ischemic stroke
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2023.1148697
Abstract: N-methyl-D-aspartate receptors (NMDARs) play a critical role in excitotoxicity caused by ischemic stroke, but NMDAR antagonists have failed to be translated into clinical practice for treating stroke patients. Recent studies suggest that targeting the specific… read more here.
Keywords: receptor complex; nmda receptor; complex potential; stroke ... See more keywords
Targeting NMDA Receptor Complex in Management of Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15101297
Abstract: N-methyl-D-aspartate receptors (NMDARs) are widely distributed in the central nervous system (CNS) and play critical roles in neuronal excitability in the CNS. Both clinical and preclinical studies have revealed that the abnormal expression or function… read more here.
Keywords: receptor complex; complex management; nmda receptor; targeting nmda ... See more keywords
Cytoplasmic interaction of LysM receptors contributes to the formation of symbiotic receptor complex.
Sign Up to like & getrecommendations! Published in 2020 at "Plant biotechnology"
DOI: 10.5511/plantbiotechnology.20.0511a
Abstract: Receptor complex formation at the cell surface is a key step to initiate downstream signaling but the contribution of this process for the regulation of the direction of downstream responses is not well understood. In… read more here.
Keywords: receptor complex; cytoplasmic interaction; lysm; receptor ... See more keywords