Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.08.026
Abstract: CNS angiogenesis and blood-brain barrier integrity are controlled by the canonical Wnt pathway. In this issue of Neuron, Cho et al. (2017) use advanced mouse genetics and biochemical experiments to unravel the ligand-specific association of membrane… read more here.
Keywords: ligand selective; wnt receptor; blood; receptor complexes ... See more keywords
Quantification of Receptor Occupancy by Ligand—An Understudied Class of Potential Biomarkers
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12102956
Abstract: Simple Summary Molecular complexes, such as those comprised of ligands such as hormones binding to their target receptors, are key determinants of health and disease. While research has focused on measuring receptors or ligands independently… read more here.
Keywords: potential biomarkers; ligand receptor; receptor complexes; receptor ... See more keywords
Establishment of models for reliability evaluation of 3CLpro ligand-receptor complexes with different binding sites.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2021-0271
Abstract: Aim: Recent research shows that 3CLpro enzyme of SARS-CoV-2 is a significant target against COVID-19. Drug modeling allows the design of inhibitors of 3CLpro, but the accuracy of those methods remains unclear. Therefore, it is important to… read more here.
Keywords: ligand receptor; evaluation 3clpro; reliability; reliability evaluation ... See more keywords