Structural heterogeneity of the μ-opioid receptor’s conformational ensemble in the apo state
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DOI: 10.1038/srep45761
Abstract: G-protein coupled receptors (GPCRs) are the largest and most pharmaceutically relevant family of membrane proteins. Here, fully unbiased, enhanced sampling simulations of a constitutively active mutant (CAM) of a class A GPCR, the μ-opioid receptor… read more here.
Keywords: state; opioid receptor; structural heterogeneity; heterogeneity opioid ... See more keywords