Discovery of Thieno[2,3-e]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability.
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DOI: 10.1021/acs.jmedchem.2c00008
Abstract: Endocrine therapies in the treatment of early and metastatic estrogen receptor α positive (ERα+) breast cancer (BC) are greatly limited by de novo and acquired resistance. Selective estrogen receptor degraders (SERDs) like fulvestrant provide new… read more here.
Keywords: estrogen receptor; estrogen; receptor degraders; selective estrogen ... See more keywords