Expression of trophoblast derived prostaglandin E2 receptor 2 (EP2) is reduced in patients with recurrent miscarriage and EP2 regulates cell proliferation and expression of inflammatory cytokines.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2020.103210
Abstract: BACKGROUD Prostaglandin E2 (PGE2), an inflammatory mediator, modulates cytokines, regulates immune responses in reproductive processes and stimulates inflammatory reactions via the prostaglandin E2 receptor 2 (EP2). However, the regulatory effects of EP2 signaling on trophoblasts… read more here.
Keywords: ep2; recurrent miscarriage; prostaglandin receptor; receptor ep2 ... See more keywords
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abf1268
Abstract: Structures of prostaglandin receptor EP2 revealed its agonists’ selectivity and G protein coupling mechanism. Selective modulation of the heterotrimeric G protein α S subunit–coupled prostaglandin E2 (PGE2) receptor EP2 subtype is a promising therapeutic strategy… read more here.
Keywords: ep2; receptor ep2; protein coupling; activation ... See more keywords