Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0976-1
Abstract: The central histaminergic nervous system, originating from the tuberomammillary nucleus (TMN) of the hypothalamus, widely innervates almost the whole brain, including the basal ganglia. Intriguingly, the histaminergic system is altered in parkinsonian patients. Yet, little… read more here.
Keywords: histamine; dopamine receptor; receptor; basal ganglia ... See more keywords
Alcohol intake enhances glutamatergic transmission from D2 receptor-expressing afferents onto D1 receptor-expressing medium spiny neurons in the dorsomedial striatum
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-019-0332-9
Abstract: Dopaminergic modulation of corticostriatal transmission is critically involved in reward-driven behaviors. This modulation is mainly mediated by dopamine D1 receptors (D1Rs) and D2Rs, which are highly expressed in medium spiny neurons (MSNs) of the dorsomedial… read more here.
Keywords: transmission; glutamatergic transmission; receptor; expressing afferents ... See more keywords
The non-receptor tyrosine kinase Pyk2 modulates acute locomotor effects of cocaine in D1 receptor-expressing neurons of the nucleus accumbens
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DOI: 10.1038/s41598-020-63426-5
Abstract: The striatum is critical for cocaine-induced locomotor responses. Although the role of D1 receptor-expressing neurons is established, underlying molecular pathways are not fully understood. We studied the role of Pyk2, a non-receptor, calcium-dependent protein-tyrosine kinase.… read more here.
Keywords: locomotor; pyk2; tyrosine; expressing neurons ... See more keywords
Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204515119
Abstract: Significance Neuropathic pain is a debilitating chronic pain condition that is poorly responsive to currently available analgesic drugs. A widespread clinical need remains for novel, safe, and efficacious nonopioid therapeutics for afflicted patients. Using a… read more here.
Keywords: neuropeptide receptor; receptor expressing; neuropathic pain; pain ... See more keywords
Analgesia by deletion of spinal neurokinin 1 receptor expressing neurons using a bioengineered substance P-Pseudomonas exotoxin conjugate
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Pain"
DOI: 10.1177/1744806917727657
Abstract: Cell deletion approaches to pain directed at either the primary nociceptive afferents or second-order neurons are highly effective analgesic manipulations. Second-order spinal neurons expressing the neurokinin 1 (NK1) receptor are required for the perception of… read more here.
Keywords: pseudomonas exotoxin; nk1 receptor; deletion; expressing neurons ... See more keywords