Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists.
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DOI: 10.1021/acs.jmedchem.0c00828
Abstract: Muscle atrophy and cachexia are common comorbidities among patients suffering from cancer, chronic obstructive pulmonary disease and several other chronic diseases. The peptide hormone ghrelin exerts pleiotropic effects including the stimulation of growth hormone secretion… read more here.
Keywords: ghrelin receptor; receptor full; growth; full agonists ... See more keywords