Conformational states of TNFR1 as a molecular switch for receptor function
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3829
Abstract: Tumor necrosis factor receptor 1 (TNFR1) is a transmembrane receptor that plays a key role in the regulation of the inflammatory pathway. While inhibition of TNFR1 has been the focus of many studies for the… read more here.
Keywords: receptor; receptor function; conformational states; molecular switch ... See more keywords
β3-adrenoceptor activation exhibits a dual effect on behaviors and glutamate receptor function in the prefrontal cortex
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113417
Abstract: β-adrenoceptor (β-AR), especially the β1- and β2-AR subtypes, is known to participate in stress-related behavioral changes. Recently, SR58611A, a brain-penetrant β3-AR agonist, exhibits anxiolytic- and antidepressant-like effects. In this study, we sought to study the… read more here.
Keywords: nmda receptor; receptor function; receptor; sr58611a ... See more keywords
Functional evolution of vertebrate sensory receptors
Sign Up to like & getrecommendations! Published in 2020 at "Hormones and Behavior"
DOI: 10.1016/j.yhbeh.2020.104771
Abstract: Sensory receptors enable animals to perceive their external world, and functional properties of receptors evolve to detect the specific cues relevant for an organism's survival. Changes in sensory receptor function or tuning can directly impact… read more here.
Keywords: evolution; evolution vertebrate; receptor function; sensory receptors ... See more keywords
The M4 Helix Is Involved in α7 nACh Receptor Function.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00027
Abstract: Nicotinic acetylcholine receptors (nAChR) are the archetypal members of the pentameric ligand-gated ion channel (pLGIC) family, an important class of cell signaling proteins. In all members of this family, each of the five subunits has… read more here.
Keywords: function; involved nach; role receptor; helix involved ... See more keywords
Structural insights into glucocorticoid receptor function.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society transactions"
DOI: 10.1042/bst20210419
Abstract: The glucocorticoid receptor (GR) is a steroid hormone-activated transcription factor that binds to various glucocorticoid response elements to up- or down- regulate the transcription of thousands of genes involved in metabolism, development, stress and inflammatory… read more here.
Keywords: insights glucocorticoid; structural insights; receptor; glucocorticoid receptor ... See more keywords
A multi-dimensional view of context-dependent G protein-coupled receptor function
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society Transactions"
DOI: 10.1042/bst20210650
Abstract: G protein-coupled receptor (GPCR) family members can sense an extraordinary variety of biomolecules to activate intracellular signalling cascades that modulate key aspects of cell physiology. Apart from their crucial role in maintaining cell homeostasis, these… read more here.
Keywords: coupled receptor; context dependent; receptor; protein coupled ... See more keywords
Altered GABAA receptor function in women with endometriosis: a possible pain-related mechanism.
Sign Up to like & getrecommendations! Published in 2023 at "Acta obstetricia et gynecologica Scandinavica"
DOI: 10.1111/aogs.14559
Abstract: INTRODUCTION The mechanism underlying endometriosis-related pain remains poorly understood. Previous studies have indicated that γ-aminobutyric acid (GABA) type A (GABAA ) receptors and GABAergic substances (eg endogenous neurosteroids) play important mechanistic roles in various pain… read more here.
Keywords: receptor; receptor function; pain; gabaa receptor ... See more keywords
Understanding inhibitory receptor function in neutrophils through the lens of CLEC12A
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13174
Abstract: Neutrophils are the first leukocytes recruited from the circulation in response to invading pathogens or injured cells. To eradicate pathogens and contribute to tissue repair, recruited neutrophils generate and release a host of toxic chemicals… read more here.
Keywords: response; receptor function; inhibitory receptor; understanding inhibitory ... See more keywords
Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators
Sign Up to like & getrecommendations! Published in 2017 at "Neural Plasticity"
DOI: 10.1155/2017/2875904
Abstract: The N-methyl-D-aspartate receptors (NMDARs) are subtype glutamate receptors that play important roles in excitatory neurotransmission and synaptic plasticity. Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases,… read more here.
Keywords: progress; nmda receptor; enhancing nmda; function recent ... See more keywords
Estrogen Receptor Function: Impact on the Human Endometrium
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.827724
Abstract: The physiological role of estrogen in the female endometrium is well established. On the basis of responses to steroid hormones (progesterone, androgen, and estrogen), the endometrium is considered to have proliferative and secretory phases. Estrogen… read more here.
Keywords: endometrium; receptor function; estrogen receptor; estrogen ... See more keywords