CEBPB regulates the bile acid receptor FXR to accelerate colon cancer progression by modulating aerobic glycolysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24703
Abstract: Aerobic glycolysis is a main characteristic of tumors, and inhibited glycolysis impedes the tumor development. Farnesoid X Receptor (FXR) mainly regulates bile acid metabolism. In this research, we mainly investigated whether FXR was involved in… read more here.
Keywords: aerobic glycolysis; receptor fxr; glycolysis; colon cancer ... See more keywords
Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.7b00363
Abstract: Farnesoid X receptor (FXR) plays a major role in the control of cholesterol metabolism. Antagonizing transcriptional activity of FXR is an effective means to treat the relevant metabolic syndrome. Some of antagonists so far have… read more here.
Keywords: fxr; receptor fxr; acylated piperidine; nonacidic chemotype ... See more keywords
Ursodeoxycholic acid (UDCA) reduces hepatocyte apoptosis by inhibiting farnesoid X receptor (FXR) in hemorrhagic shock (HS).
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220525152811
Abstract: BACKGROUND Hemorrhagic shock (HS) is the most common cause of potentially preventable death after traumatic injury. Acute liver injury is an important manifestation of HS. Apoptosis plays an important role in liver injury. Farnesoid X… read more here.
Keywords: farnesoid receptor; apoptosis; group; receptor fxr ... See more keywords
Transcriptional Control of Trpm6 by the Nuclear Receptor FXR
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23041980
Abstract: Farnesoid x receptor (FXR) is a nuclear bile acid receptor that belongs to the nuclear receptor superfamily. It plays an essential role in bile acid biosynthesis, lipid and glucose metabolism, liver regeneration, and vertical sleeve… read more here.
Keywords: nuclear receptor; receptor fxr; fxr; receptor ... See more keywords
Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28062840
Abstract: Compounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary… read more here.
Keywords: farnesoid receptor; oxadiazole derivatives; receptor fxr; fxr antagonists ... See more keywords